718639-87-3

Upstream product

• 2346-74-9 6-chloro-9-methyl-9H-purine 
• 87-42-3 6-chloropurine 
• 459-57-4 4-fluorobenzaldehyde 
• 718639-84-0 2-[methyl(9-methyl-9H-purin-6-yl)amino]ethanol 

Relevant academic research and scientific papers

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their biological activities, 5-(4-{2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy} benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.