71865-37-7 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 71865-37-7 differently. You can refer to the following data:
1. A sulfhydryl reactive homobifunctional crosslinking reagent.
Spacer Arm: 13.3 Angstroms
2. A sulfhydryl reactive homobifunctional crosslinking reagent.Spacer Arm: 13.3 Angstroms
General Description
DTME is a homobifunctional, maleimide crosslinker for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. DTME is similar in length to BMH but differs in containing a disulfide bond in its spacer arm, allowing crosslinks with DTME to be cleaved with reducing agent such as dithiothreitol (DTT).
Check Digit Verification of cas no
The CAS Registry Mumber 71865-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,8,6 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 71865-37:
(7*7)+(6*1)+(5*8)+(4*6)+(3*5)+(2*3)+(1*7)=147
147 % 10 = 7
So 71865-37-7 is a valid CAS Registry Number.
71865-37-7Relevant articles and documents
Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering
Dispinar, Tugba,Van Camp, Wim,De Cock, Liesbeth J.,De Geest, Bruno G.,Du Prez, Filip E.
experimental part, p. 383 - 394 (2012/06/30)
A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering.