7187-47-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(1H-BENZIMIDAZOL-2-YL)-1,3-THIAZOL-2-AMINE is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and heterocyclic nature make it a promising candidate for the synthesis of various therapeutic agents. It may be utilized in the design and synthesis of novel compounds with potential applications in treating various diseases and medical conditions.
Used in Agriculture:
In the agricultural industry, 4-(1H-BENZIMIDAZOL-2-YL)-1,3-THIAZOL-2-AMINE may be used as a chemical component in the development of new pesticides, herbicides, or plant growth regulators. Its heterocyclic structure could provide unique properties that enhance the effectiveness of these agricultural chemicals, leading to improved crop protection and yield.
Used in Material Science:
4-(1H-BENZIMIDAZOL-2-YL)-1,3-THIAZOL-2-AMINE may also find applications in the field of material science. Its heterocyclic structure and the presence of nitrogen and sulfur atoms could contribute to the development of new materials with unique properties, such as improved conductivity, stability, or reactivity. 4-(1H-BENZIMIDAZOL-2-YL)-1,3-THIAZOL-2-AMINE could be used in the synthesis of advanced materials for various applications, including electronics, energy storage, or environmental protection.

InChI:InChI=1/C10H8N4S/c11-10-14-8(5-15-10)9-12-6-3-1-2-4-7(6)13-9/h1-5H,(H2,11,14)(H,12,13)

Upstream product

• 939-70-8 2-acetylbenzimidazole 
• 17356-08-0 thiourea 
• 10227-63-1 1-(1H-benzo[d]imidazol-2-yl)-2-bromoethanone 

Downstream Products

• 1427160-26-6 [4-(1H-benzoimidazol-2-yl)thiazol-2-yl](benzylidene)amine 
• 1427160-27-7 [4-(1H-benzoimidazol-2-yl)thiazol-2-yl](4-nitrobenzylidene)amine 
• 1427160-28-8 [4-(1H-benzoimidazol-2-yl)thiazol-2-yl](4-bromobenzylidene)amine 
• 1427160-29-9 N-(4-methoxybenzylidene)-4-(1H-benzo[d]imidazol-2-yl)thiazol-2-amine 
• 1443114-18-8 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetic acid 
• 1443114-16-6 2,6-difluoro-N-(4-(1-isopropyl-1H-benzo[d]imidazol-2-yl)thiazol-2-yl)benzamide 
• 1443114-17-7 ethyl 2-(2-(2-(2,6-difluorobenzamido)thiazol-4-yl)-1H-benzo[d]imidazol-1-yl)acetate 
• 1443114-15-5 N-(4-(1H-benzo[d]imidazol-2-yl)thiazol-2-yl)-2,6-difluorobenzamide 

Relevant academic research and scientific papers

Synthesis of Some Benzimidazole-based Heterocycles and their Application as Copper Corrosion Inhibitors

A series of new substituted benzimidazoles embedded with a variety of function groups has been synthesized from N-methyl-2-bromoacetylbenzimidazole. The synthesized compounds were fully characterized, and their structures were elucidated based on elemental analysis, spectral data, and alternative synthetic pathways, whenever possible. Some of benzimidazole derivatives were tested as corrosion inhibitors.

Synthesis of some new benzimidazole-thiazole derivatives as anticancer agents

4-(1H-benzo[d]imidazol-2-yl)thiazol-2-amine and its 1-methyl derivative (1) were reacted with different reagents such as acid anhydrides, malononitrile, chloroacetyl chloride, and aromatic aldehydes to produce the corresponding benzimidazole products 2-9, respectively. Also, 2-chloro-N-(4-(1-methyl-1H-benzo[d] imidazol-2-yl)thiazol-2-yl) acetamide (6) was reacted with diaminoethane, ortho-substituted aniline, thioglycolic acid, thiosemicarbazide derivatives, secondary amines, and potassium isothiocyanate to afford the corresponding derivatives 10-17, respectively. The cytotoxic activity of some newly synthesized derivativeswas studied against two different cell lines HepG2 and PC12. Compounds 9 and 15b showed promising anticancer activity against both types of the tested cancerous cell lines.

Synthesis and biological evaluation of some novel [4-(1H-Benzoimidazol-2- yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2- yl]-N'-benzylidene-hydrazines

A new family of thiazole heterocycles, namely [4-(1H-benzoimidazol-2-yl)- thiazol-2-yl]-benzylidene-amines has been synthesized by the condensation of 4-(1H-Benzoimidazol-2-yl)-thiazol-2-ylamine with various aromatic aldehydes and N-[4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines through the cyclization of 1-(1H-benzoimidazol-2-yl)-2-bromo-ethanone with arylthiosemicarbazones. The target compounds are achieved by using 1-(1H-Benzoimidazol-2-yl)-ethanone as starting material. The chemical structures of all newly synthesized compounds were confirmed by their IR, 1H NMR and Mass spectral data. Further the compounds were used to evaluate their antimicrobial activity and found that the appreciable antimicrobial activity by some of the title compounds.

Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol- 2yl)-1,3-thiazol-2-amines

A new series of novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines 5a-d and 4-(1H-benz[d]imidazol-2yl)-3-alkyl-2,3-dihydro-1,3-thiazol-2-amine 8a-d has been synthesized by the cyclocondensation of 2-acetyl benzimidiazoles 4a-d and 2-bromo-1-(1-alkyl-1H