71878-79-0Relevant articles and documents
Synthesis of Steroidal 17β-Carboxamide Derivatives
Formstecher, P.,Lustenberger, P.,Dautrevaux, M.
, p. 265 - 272 (2007/10/02)
Several 17β-carboxamide derivatives of natural and fluorinated glucocorticoids have been synthesized.The 17β-carboxylic derivatives were obtained by periodic acid oxidation of their side chains.They were then activated by N-hydroxybenzotriazole (HOBT) and coupled to several primary amines.Using this method eleven 17β-carboxamide derivatives have been prepared in good yields.