7188-93-4

Upstream product

• 50-00-0 formaldehyd 
• 133145-92-3 1-phenylpropan-1-one O-acetyl oxime 
• 62-53-3 aniline 
• 77987-87-2 (4-Methyl-2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)-phenyl-methanone 
• 77987-93-0 (4-Methyl-2,5-diphenyl-3,4-dihydro-2H-pyrazol-3-yl)-phenyl-methanone oxime 
• 67652-99-7 (+/-)_S-(E)-1-(phenylsulfinyl)prop-1-ene 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 28691-72-7 (E)-1-propenyl phenyl sulfone 

Relevant academic research and scientific papers

Practical synthesis of pyrazoles via a copper-catalyzed relay oxidation strategy

Various 1,3- and 1,3,4-substituted pyrazoles are smoothly formed via copper-catalyzed cascade reactions of oxime acetates, amines and aldehydes. This relay oxidative process involves copper-promoted N-O bond cleavage and C-C/C-N/N-N bond formations to furnish pyrazolines, and sequential Cu-O2 system-involved oxidative dehydrogenation of pyrazolines to afford pyrazoles. This transformation provides a novel and versatile approach for the synthesis of pyrazoles, with an inexpensive copper catalyst and green oxidants. It is atom- and step-economical, and possesses a good functional group tolerance, as well as operational simplicity. This journal is