719-70-0

Basic information

• Product Name: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE
• Synonyms: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE;BUTTPARK 45\09-69;N-(4-FLUORO-2-NITRO-PHENYL)-PIPERIDINE
• CAS NO: 719-70-0
• Molecular Formula: C₁₁H₁₃FN₂O₂
• Molecular Weight: 224.23
• Product Categories: Amines;blocks;FluoroCompounds;NitroCompounds;Piperidine
• Mol File: 719-70-0.mol

Chemical Properties

• Boiling Point: 353.2°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: /Solid
• Density: 1.261g/cm³
• Vapor Pressure: 3.64E-05mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(719-70-0)
• EPA Substance Registry System: 1-(4-FLUORO-2-NITROPHENYL)PIPERIDINE(719-70-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 719-70-0(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(4-Fluoro-2-nitrophenyl)piperidine is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
2. Used in Chemical Research:
1-(4-Fluoro-2-nitrophenyl)piperidine is used as a research tool in the field of organic chemistry. Its properties and reactivity can be studied to gain insights into the behavior of similar compounds and to develop new synthetic methods or strategies.
3. Used in Material Science:
1-(4-Fluoro-2-nitrophenyl)piperidine is used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of novel materials with enhanced stability, reactivity, or other desirable characteristics.
4. Used in Environmental Applications:
1-(4-Fluoro-2-nitrophenyl)piperidine may be used in the development of environmental remediation technologies. Its reactivity could potentially be harnessed to degrade pollutants or to facilitate the removal of contaminants from the environment.

InChI:InChI=1/C11H13FN2O2/c12-9-4-5-10(11(8-9)14(15)16)13-6-2-1-3-7-13/h4-5,8H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 364-74-9 1,4-difluoro-2-nitrobenzene 

Downstream Products

• 252758-87-5 5-fluoro-2-(piperidin-1-yl)aniline 

Relevant articles and documents

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex proteins. Here, we report discovery of the first inhibitors selective for ERAP1 over its paralogues ERAP2 and IRAP. Compound 1 (N-(N-(2-(1H-indol-3-yl)ethyl)carbamimidoyl)-2,5-difluorobenzenesulfonamide) and compound 2 (1-(1-(4-acetylpiperazine-1-carbonyl)cyclohexyl)-3-(p-tolyl)urea) are competitive inhibitors of ERAP1 aminopeptidase activity. Compound 3 (4-methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid) allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates. Compounds 2 and 3 inhibit antigen presentation in a cellular assay. Compound 3 displays higher potency for an ERAP1 variant associated with increased risk of autoimmune disease. These inhibitors provide mechanistic insights into the determinants of specificity for ERAP1, ERAP2, and IRAP and offer a new therapeutic approach of specifically inhibiting ERAP1 activity in vivo.

METHOD OF REGULATING PHOSPHORYLATION OF SR PROTEIN AND ANTIVIRAL AGENTS COMPRISING SR PROTEIN ACTIVITY REGULATOR AS THE ACTIVE INGREDIENT

The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhi

Methine dyes

The invention relates to a new class of pyrrolobenzimidazole, benzimidazoloisoquinoline and dipyrodinobenzodiimidazole in cyanine sensitizing dyes derived therefrom and their use in silver halide emulsions, and to methods for preparation of such new dyes.