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6-chloro-3-(4'-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine is a complex organic chemical compound with the molecular formula C10H7ClN4O. It features a triazolo[4,3-b]pyridazine core structure, which is a fused ring system consisting of a triazole and a pyridazine. The compound has a chlorine atom at the 6-position and a methoxyphenyl group at the 3-position, which is a phenyl ring with a methoxy (-OCH3) substituent attached to the 4' position. This specific arrangement of functional groups and atoms gives the compound unique chemical properties and potential applications in various fields, such as pharmaceuticals or materials science. Due to its complex structure, it is typically synthesized through multi-step organic reactions and is of interest to researchers studying the properties and potential uses of heterocyclic compounds.

7190-82-1

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7190-82-1 Usage

General Description

6-chloro-3-(4'-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine is a chemical compound with the molecular formula C11H9ClN4O. It is a triazolopyridazine derivative with a chlorine atom and a 4'-methoxyphenyl group attached to the triazolo ring. 6-chloro-3-(4'-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine has potential pharmaceutical applications due to its biological activities, including its role as an antitumor agent and its ability to inhibit the growth of cancer cells. Research on this chemical's properties and potential uses is ongoing, and it is of interest to the scientific and medical communities for its potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 7190-82-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,9 and 0 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7190-82:
(6*7)+(5*1)+(4*9)+(3*0)+(2*8)+(1*2)=101
101 % 10 = 1
So 7190-82-1 is a valid CAS Registry Number.

7190-82-1Relevant academic research and scientific papers

Synthesis and bioevaluation of 6-chloropyridazin-3-yl hydrazones and 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines as cytotoxic agents

Mamta,Aggarwal, Ranjana,Sadana, Rachna,Ilag, Jeziel,Sumran, Garima

, p. 288 - 295 (2019/02/12)

An efficient synthesis of a series of 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines is described via intramolecular oxidative cyclization of various 6-chloropyridazin-3-yl hydrazones with iodobenzene diacetate. The structures of the newly synth

TRIAZOLOPYRIDAZINE COMPOUNDS, USE AS INHIBITORS OF THE KINASE LRRK2, AND METHODS FOR PREPARATION THEREOF

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Paragraph 0101, (2013/11/19)

The present invention provides novel LRRK2 kinase inhibitors and methods of treating disease states using these inhibitors.

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

Grey, Ron,Pierce, Albert C.,Bemis, Guy W.,Jacobs, Marc D.,Moody, Cameron Stuver,Jajoo, Rahul,Mohal, Narinder,Green, Jeremy

scheme or table, p. 3019 - 3022 (2010/01/16)

A series of substituted 3-aryl-6-amino-triazolo[4,3-b]pyridazines were identified as highly selective inhibitors of Pim-1 kinase. Initial exploration identified compound 24 as a potent, selective inhibitor, limited in its utility by poor solubility and permeability. Understanding the unusual ATP-binding site of the Pim kinases and X-ray crystallographic data on compound 24 led to design improvements in this class of inhibitor. This resulted in compound 29, a selective, soluble and permeable inhibitor of Pim-1.

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