7191-46-0

Usage

InChI:InChI=1/C8H6I2O2/c1-4(11)6-2-5(9)3-7(10)8(6)12/h2-3,12H,1H3

Upstream product

• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 141213-92-5 2-(4-Bromo-2-methoxy-phenyl)-3-hydroxy-6,8-diiodo-chromen-4-one 
• 1431664-18-4 C₁₁H₁₁I₂NO₂ 
• 1431664-32-2 C₂₂H₁₆I₂N₂O₃S 
• 1431664-27-5 C₁₆H₁₂I₂N₂O₃S 
• 1431664-22-0 C₁₈H₁₇I₂NO₄S 
• 146517-67-1 (E)-3-(4-Chloro-naphthalen-1-yl)-1-(2-hydroxy-3,5-diiodo-phenyl)-propenone 
• 141213-83-4 (E)-3-(4-Bromo-2-methoxy-phenyl)-1-(2-hydroxy-3,5-diiodo-phenyl)-propenone 

Relevant academic research and scientific papers

Pyridinium lodochloride: An efficient reagent for lodination of hydroxylated aromatic ketones and aldehydes

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.

NaIO4/KI/NaCl: a new reagent system for iodination of activated aromatics through in situ generation of iodine monochloride

A new reagent system consisting of NaIO4/KI/NaCl in aq AcOH has been found to be effective in iodinating a variety of activated aromatic substrates via in situ-generated iodine monochloride, to furnish iodoaromatics in excellent yields. This iodination procedure has been applied successfully for a cost-effective synthesis of 3,3′-diaminobenzidine, a key intermediate for preparing proton conducting membranes for fuel cell applications, with high yield and a purity of 99.7%.

Reaction of 4-(2′-hydroxyaryl)-1,3-dithiolium salts with sodium sulfide. A selective synthesis of 2′-hydroxyacetophenones

The treatment of 4-(2′-hydroxyaryl)-2-(N,N-dialkylamino)-1,3-dithiolium perchlorates (1a-g) with sodium sulfide nonahydrate in ethanol at room temperature affords the corresponding 1,3-dithiole-2-thiones (2a-g). When these reactions are conducted in boiling ethanol, 2′-hydroxyacetophenones (3a-g) have been obtained in good to excellent yield. A tentative mechanism for the formation of 3a-g shows that this reaction is regioselective, this being established by the presence of hydroxyl group in 2′-position. That has been confirmed in a control experiment, 4-phenyl-2-(piperidin-1-yl)-1,3-dithiolium perchlorate affording a mixture of condensation products of acetophenone and phenylacetaldehyde, under similar reaction conditions.

Synthesis of new hydroxyacetophenones by using iodine and iodic acid

Iodine and iodic acid mixture has been used as a reagent for iodination of hydroxyacetophenones, and some new hydroxyiodoacetophenones are prepared.