7191-86-8Relevant academic research and scientific papers
Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition
Chaudhary, Priyanka,Gupta, Surabhi,Muniyappan, Nalluchamy,Sabiah, Shahulhameed,Kandasamy, Jeyakumar
, p. 104 - 119 (2019/01/08)
Regioselective ring nitration of N-alkyl anilines is reported using tert-butyl nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively.
CFTR REGULATORS AND METHODS OF USE THEREOF
-
Paragraph 0025; 0580, (2017/07/14)
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders..
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation
Cil, Onur,Phuan, Puay-Wah,Son, Jung-Ho,Zhu, Jie S.,Ku, Colton K.,Tabib, Niloufar Akhavan,Teuthorn, Andrew P.,Ferrera, Loretta,Zachos, Nicholas C.,Lin, Ruxian,Galietta, Luis J.V.,Donowitz, Mark,Kurth, Mark J.,Verkman, Alan S.
, p. 14 - 4,26 (2017/03/22)
Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a phenylquinoxalinone activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride chan
Metal-free TEMPO-promoted C(sp3)-H amination to afford multisubstituted benzimidazoles
Xue, Ding,Long, Ya-Qiu
, p. 4727 - 4734 (2014/06/09)
An efficient TEMPO-air/cat. TEMPO-O2 oxidative protocol was developed to synthesize multisubstituted or fused tetracyclic benzimidazoles via a metal-free oxidative C-N coupling between the sp3 C-H and free N-H of readily available N1-benzyl/alkyl-1,2-phenylenediamines.
