71916-44-4Relevant academic research and scientific papers
7-(Triflluoromethyl)-4-aminoquinoline Hypotensives: Novel Peripheral Sympatholytics
McCall, John M.,TenBrink, R. E.,Kamdar, Bharat V.,Skaletzky, Louis L.,Perricone, Salvatore C.,et al.
, p. 133 - 137 (2007/10/02)
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described.Structure-activity relationships in this series have been elucidated.Some of the more potent hypotensives were evalu
Antihypertensive 7-trifluoromethyl-4-aminoquinolones
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, (2008/06/13)
Antihypertensive compounds of the formula II STR1 wherein D is a piperidino or 1,2,5,6-tetrahydropyridino ring; wherein X is chloro or trifluoromethyl; wherein R1 is hydrogen or hydroxy when the D ring is piperidino, or nothing when the D ring is 1,2,5,6-tetrahydropyridino; and, wherein the moiety Ar is 2-oxo-1-benzimidazolinyl, phenyl, or phenyl substituted by one or two halo, trifluoromethyl, or alkyl, alkoxy, in which the carbon moieties are of 1 to 3 carbon atoms, inclusive, and halo is chloro, bromo, or fluoro, are produced by reacting 4-[[7-(chloro) or (trifluoromethyl)-4-quinolinyl]-amino]benzoic acid with thionyl chloride or a carbonyl diimidazole and subsequent reaction with the selected substituted piperidine or 1,2,5,6-tetrahydropyridine. The pharmacologically acceptable acid addition salts of II can also be used as antihypertensives.
