71916-57-9

Usage

Uses

Used in Pharmaceutical Industry:
4-M-TOLYL-PIPERIDIN-4-OL is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and ability to be incorporated into a wide range of drug molecules.
Used in Chemical Manufacturing:
4-M-TOLYL-PIPERIDIN-4-OL is used as a building block for the manufacturing of chemicals and other organic compounds, contributing to the development of new chemical entities and products.
Used in Fragrance and Flavoring Industry:
4-M-TOLYL-PIPERIDIN-4-OL is used as a component in the production of fragrances and flavorings, adding to the diversity of scents and tastes in various consumer products.

Upstream product

• 634466-57-2 1-benzyl-4-(3-methyl-phenyl)-piperidin-4-ol 
• 198648-99-6 tert-butyl 4-hydroxy-4-(3-methylphenyl)-1-piperidinecarboxylate 

Downstream Products

• 188607-07-0 11-[4-Hydroxy-4-(3-methylphenyl)piperidine-1-yl]-2-methyl-6,11-dihydrodibenzo[b,e] oxepine 
• 71916-56-8 4-(3-methylphenyl)-4-hydroxy-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperidine 

Relevant academic research and scientific papers

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.

Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.

INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole compound of the following formula (I), a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate:

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.