71919-14-7

Upstream product

• 1118-68-9 dimethylaminoacetic acid 
• 21616-46-6 3-hydroxymethyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 57-41-0 phenythoin 

Downstream Products

• 71919-15-8 3-(hydroxymethyl)-5,5-diphenylhydantoin N,N-dimethylglycine ester, monomethanesulfonate salt 

Relevant academic research and scientific papers

Phenytoin prodrugs III: Water-soluble prodrugs for oral and/or parenteral use

Various bioreversible derivatives of phenytoin, a poorly water soluble and erratically absorbed drug after both oral and parenteral dosing, were synthesized. Initial evaluation of these expected prodrugs, i.e., their aqueous solubility, cleavage in the presence of various animal tissues, and anticonvulsant activity in mice, confirmed that a number of the derivatives did indeed behave as prodrugs. The more promising prodrugs were the disodium phosphate ester and various amino groups containing acyl esters of 3-(hydroxymethyl)-5,5-diphenylhydantoin.

Derivatives of 5,5-diphenylhydantoin exhibiting enhanced solubility and the therapeutic use thereof

Novel derivatives of 5,5-diphenylhydantoin, having the formula: STR1 wherein R is as defined in the specification and claims hereinafter, are disclosed. These compounds exhibit enhanced solubility over diphenylhydantoin per se and find therapeutic usefulness as anticonvulsants, antiepileptics and antiarrhythmics.