719268-92-5

Basic information

• Product Name: 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
• Synonyms: 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE;3-FLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER;5-Fluoropyridinyl-3-boronicacidpinacolate;3-Fluoro-5-(4,4,5,5-tetraMethy-[1,3,2]dioxaborolan-2-yl)pyridine;5-Fluoropyridin-3-ylboronic acid pinacol ester;3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(5-Fluoropyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
• CAS NO: 719268-92-5
• Molecular Formula: C₁₁H₁₅BFNO₂
• Molecular Weight: 223.0517032
• Product Categories: Boronic ester;Organoborons;Pyridine
• Mol File: 719268-92-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 55.0 to 59.0 °C
• Boiling Point: 294.487 °C at 760 mmHg
• Flash Point: 131.901 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.477
• PKA: 2.80±0.22(Predicted)
• CAS DataBase Reference: 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(719268-92-5)
• EPA Substance Registry System: 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(719268-92-5)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 719268-92-5(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine is a chemical compound with a complex structure containing elements like fluorine, boron, and carbon. Due to its structure, it plays an essential role in organic chemistry as it offers a fluorine atom and a boron-containing functional group. While this chemical might be involved in numerous reactions, it frequently participates in the Suzuki coupling, a popular type of palladium-catalyzed cross-coupling reaction, hence it is a valued reagent in medicinal chemistry and agricultural chemistry. The tetramethyl-[1,3,2]dioxaborolane part of the molecule acts as a boron source for this reaction. Overall, due to its unique features, this chemical is significant for the development of a variety of organic reactions, potentially including the creation of pharmaceutical products or agrochemicals.

InChI:InChI=1/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 452972-09-7 (5-bromopyridin-3-yl)boronic acid 
• 372-47-4 3-Fluoropyridine 
• 73183-34-3 bis(pinacol)diborane 
• 407-20-5 3-bromo-5-fluoropyridine 
• 462652-75-1 trifluoromethanesulfonic acid 5-fluoropyridin-3-yl ester 

Downstream Products

• 1151798-74-1 4-(5-fluoropyridin-3-yl)-2-nitro-6-(pyrimidin-2-yl)benzenamine 
• 1575608-76-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-fluoropyridin-5-yl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-48-1 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-fluoropyridin-5-yl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1035345-67-5 (4-(3-fluoro-5-(5-fluoropyridin-3-yl)phenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)methanamine 

Relevant articles and documents

Enzyme-like Supramolecular Iridium Catalysis Enabling C?H Bond Borylation of Pyridines with meta-Selectivity

The use of secondary interactions between substrates and catalysts is a promising strategy to discover selective transition metal catalysts for atom-economy C?H bond functionalization. The most powerful catalysts are found via trial-and-error screening due to the low association constants between the substrate and the catalyst in which small stereo-electronic modifications within them can lead to very different reactivities. To circumvent these limitations and to increase the level of reactivity prediction in these important reactions, we report herein a supramolecular catalyst harnessing Zn???N interactions that binds to pyridine-like substrates as tight as it can be found in some enzymes. The distance and spatial geometry between the active site and the substrate binding site is ideal to target unprecedented meta-selective iridium-catalyzed C?H bond borylations with enzymatic Michaelis–Menten kinetics, besides unique substrate selectivity and dormant reactivity patterns.

Azaindole derivative myelocyte proliferation inhibitor, preparation method thereof, and application of inhibitor in pharmacy

The invention provides an azaindole derivative myeloid proliferation inhibitor as shown in a formula I. In the formula, R1, R2 and R33 are as defined in the specification. The compound shown in the formula I can be used for remarkably inhibiting the proliferation of myeloid cells represented by MOLM-16, HL-60 and MV-4-11 and related diseases of the myeloid cells. The compound shown in the formula I or the salt thereof or the related pharmaceutical composition provided by the invention has excellent in-vivo and in-vitro inhibitory activity, good druggability and high bioavailability, and does not have obvious injury to visceral organs. Therefore, the compound shown in the formula I or the salt thereof and the related pharmaceutical composition have huge clinical application prospects.

SOLID FORMS OF 1-ETHYL-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA

Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)- 1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline 1- ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and m