719288-30-9

Basic information

• Product Name: 4'-acetamido-2'-benzyloxy-2-[4-(benzyloxycarbonyl)piperazin-1-yl]acetophenone
• Synonyms: 4'-acetamido-2'-benzyloxy-2-[4-(benzyloxycarbonyl)piperazin-1-yl]acetophenone
• CAS NO: 719288-30-9
• Molecular Weight: 501.582
• Mol File: 719288-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-acetamido-2'-benzyloxy-2-[4-(benzyloxycarbonyl)piperazin-1-yl]acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-acetamido-2'-benzyloxy-2-[4-(benzyloxycarbonyl)piperazin-1-yl]acetophenone(719288-30-9)
• EPA Substance Registry System: 4'-acetamido-2'-benzyloxy-2-[4-(benzyloxycarbonyl)piperazin-1-yl]acetophenone(719288-30-9)

Safety Data

• Hazardous Substances Data: 719288-30-9(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 40547-58-8 N-(4-acetyl-3-hydroxyphenyl)acetamide 
• 6317-89-1 3-acetamidophenyl acetate 
• 719288-29-6 N-[3-benzyloxy-4-(2,2-dibromo-acetyl)-phenyl]-acetamide 
• 719288-28-5 N-(4-acetyl-3-benzyloxy-phenyl)-acetamide 
• 126656-57-3 N-[3-benzyloxy-4-(2-bromo-acetyl)-phenyl]-acetamide 
• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 

Downstream Products

• 1374846-34-0 4-[1-(4-acetylamino-2-benzyloxy-benzoyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester 
• 719287-79-3 3-[4-acetamido-2-hydroxyphenyl]-4-(piperazin-1-yl)-1H-pyrazole 
• 719288-31-0 3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole 

Relevant articles and documents

PYRAZOLE COMPOUNDS

Compounds of formula (IA) or (IB) or a salt, N-oxide, hydrate or solvate thereof are inhibitors of HSP90, and are of value in the treatment of diseases responsive to HSP90 inhibition such as cancers. In the formulae, Ar is an aryl, aryl(C1-C6 alkyl), aryl(C1-C6 alkyl), heteroaryl, heteroarylaryl(C1-C6 alkyl), or heteroarylaryl(C1-C6 alkyl) group, any of which being optionally substituted in the aryl or heteroaryl part thereof; R1, is hydrogen or optionally substituted Cl-C6 alkyl; R2 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6 alkenyl, or Cl-C6 alkynyl; or a carboxyl, carboxamide or carboxyl ester group; and ring A is a non aromatic carbocyclic or heterocyclic ring wherein (i) a ring carbon is optionally substituted, and/or (ii) a ring nitrogen is optionally substituted by a group of formula -(Alk1)p (Cyc)n-(Alk3)m-(Z)r (Alk2)s Q where Alk1, Alk2 and Alk3 are optionally substituted C1-C3 alkyl, Cyc is an optionally substituted carbocyclic or heterocyclic radical; m, n, p, r and s are independently 0 or 1, Z is -0-, -S-, -(C=O)-, -S02-, -C(=O)O-, -OC(=O)-, -NW-, -C(=O)NRA-, -NRAC(=O)-, -SO2NRA- , or -NRASO2- wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical.