719296-53-4Relevant academic research and scientific papers
Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors
Wendt, Michael D.,Geyer, Andrew,McClellan, William J.,Rockway, Todd W.,Weitzberg, Moshe,Zhao, Xumiao,Mantei, Robert,Stewart, Kent,Nienaber, Vicki,Klinghofer, Vered,Giranda, Vincent L.
, p. 3063 - 3068 (2004)
Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or unsaturated rings improved inhibitor performance; substitution with sulfones
Urokinase inhibitors
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, (2008/06/13)
Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
Ukokinase inhibitors
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, (2008/06/13)
Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
