719298-94-9

Basic information

• Product Name: Acetic acid 5-((E)-2-cyano-vinylamino)-4-iodo-2-methyl-phenyl ester
• CAS NO: 719298-94-9
• Molecular Weight: 342.136
• Mol File: 719298-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid 5-((E)-2-cyano-vinylamino)-4-iodo-2-methyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 5-((E)-2-cyano-vinylamino)-4-iodo-2-methyl-phenyl ester(719298-94-9)
• EPA Substance Registry System: Acetic acid 5-((E)-2-cyano-vinylamino)-4-iodo-2-methyl-phenyl ester(719298-94-9)

Safety Data

• Hazardous Substances Data: 719298-94-9(Hazardous Substances Data)

Upstream product

• 99-55-8 2-methyl-5-nitroaniline 
• 6162-76-1 cyanoacetaldehyde 
• 719299-02-2 acetic acid 5-amino-4-iodo-2-methyl-phenyl ester 
• 54362-24-2 2-acetoxy-4-nitrotoluene 
• 61995-11-7 3-acetoxy-4-methylaniline 
• 5428-54-6 2-methyl-5-nitrophenol 

Downstream Products

• 719299-15-7 6-hydroxy-5-methyl-1H-indole-3-carbonitrile 
• 719299-12-4 acetic acid 3-cyano-5-methyl-1H-indol-6-yl ester 
• 719299-13-5 acetic acid 1-acetyl-3-cyano-5-methyl-1H-indol-6-yl ester 

Relevant articles and documents

Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid

Based on the promising activity of an indole-3-carboxamide derivative, a nonphenolic analog of mycophenolic acid (MPA), we report herein the synthesis of a compound containing two important features for the activity of MPA, the ring methoxy and methyl. The synthesis was accomplished using two strategies; a method dependent on stepwise building of the hexenoate side chain followed by the indolecarboxamide ring system, and a convergent route that depended on 1,3-sigmatropic rearrangement as a key step. Docking experiments on both Chinese Hamster and Human Type-II inosine monophosphate dehydrogenase (IMPDH) showed that this compound has potential binding interactions with the NAD site. The analogs showed no activity against MCF7-S, MCF7-R, or IGR-OV1 cancer cells.