719301-88-9

Basic information

• Product Name: (R)-4-(Bromomethyl-dimethyl-silanyloxy)-4-cyclohexyl-2-methylene-butyric acid ethyl ester
• Synonyms: (R)-4-(Bromomethyl-dimethyl-silanyloxy)-4-cyclohexyl-2-methylene-butyric acid ethyl ester
• CAS NO: 719301-88-9
• Molecular Weight: 377.394
• Mol File: 719301-88-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-(Bromomethyl-dimethyl-silanyloxy)-4-cyclohexyl-2-methylene-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(Bromomethyl-dimethyl-silanyloxy)-4-cyclohexyl-2-methylene-butyric acid ethyl ester(719301-88-9)
• EPA Substance Registry System: (R)-4-(Bromomethyl-dimethyl-silanyloxy)-4-cyclohexyl-2-methylene-butyric acid ethyl ester(719301-88-9)

Safety Data

• Hazardous Substances Data: 719301-88-9(Hazardous Substances Data)

Upstream product

• 16532-02-8 bromomethyldimethylsilyl chloride 

Relevant articles and documents

Highly diastereoselective 7-endo radical cyclization of ethyl α-methylene-γ-(bromomethyl)dimethylsiloxycarboxylates

The 7-endo radical cyclization of (bromomethyl)dimethylsilyl ethers derived from ethyl γ-hydroxy-α-methylenecarboxylates bearing a bulky γ-substituent such as isopropyl, cyclohexyl, and tert-butyl groups in tetrahydrofuran gave preferentially cyclic silyl ethers bearing the ethoxycarbonyl group anti to the γ-substituents in high yields. Treatment of the cyclic silyl ethers with silica gel gave acyclic ethyl γ-hydroxy-α-[2-(hydroxydimethylsilyl)ethyl]carboxylates. The reduction of the cyclization products with DIBAL followed by Tamao oxidation gave the corresponding acyclic triols.