719307-69-4Relevant academic research and scientific papers
Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors
Glossop, Melanie S.,Bazin, Richard J.,Dack, Kevin N.,Fox, David N.A.,MacDonald, Graeme A.,Mills, Mark,Owen, Dafydd R.,Phillips, Chris,Reeves, Keith A.,Ringer, Tracy J.,Strang, Ross S.,Watson, Christine A.L.
scheme or table, p. 3404 - 3406 (2011/07/07)
Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2′ subsite within NEP. Structural optimisation led to
CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS
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Page 40 - 41, (2010/02/07)
The invention relates to NEP inhibitors for treating cardiovascular disorders wherein R1 is C1-C6alkyl, C1-C6alkoxyC1-C3alkyl or C1-C6alkoxyC1-C
