71937-06-9Relevant academic research and scientific papers
A ratiometric fluorescent pH probe based on aggregation-induced emission enhancement and its application in live-cell imaging
Song, Panshu,Chen, Xiaotong,Xiang, Yu,Huang, Lei,Zhou, Zhaojuan,Wei, Ruirui,Tong, Aijun
, p. 13470 - 13475 (2011)
A ratiometric fluorescent pH probe, 4-carboxylaniline-5- chlorosalicylaldehyde Schiff base (1) was synthesized via a facile reaction and used for pH sensing in live cells. While exhibiting weak fluorescence when dispersed in solution, 1 displayed aggregat
4-aminobenzoic acid derivatives: Converting folate precursor to antimicrobial and cytotoxic agents
Brablíková, Michaela,Jan?ourek, Ond?ej,Janou?ek, Ji?í,Kone?ná, Klára,Krátky, Martin,Stola?íková, Ji?ina,Trejtnar, Franti?ek,Vin?ová, Jarmila
, (2020/01/25)
4-aminobenzoic acid (PABA), an essential nutrient for many human pathogens, but dispensable for humans, and its derivatives have exhibited various biological activities. In this study, we combined two pharmacophores using a molecular hybridization approach: this vitamin-like molecule and various aromatic aldehydes, including salicylaldehydes and 5-nitrofurfural, via imine bond in one-step reaction. Resulting Schiff bases were screened as potential antimicrobial and cytotoxic agents. The simple chemical modification of non-toxic PABA resulted in constitution of antibacterial activity including inhibition of methicillin-resistant Staphylococcus aureus (minimum inhibitory concentrations, MIC, from 15.62 μM), moderate antimycobacterial activity (MIC ≥ 62.5 μM) and potent broad-spectrum antifungal properties (MIC of ≥ 7.81 μM). Some of the Schiff bases also exhibited notable cytotoxicity for cancer HepG2 cell line (IC50 ≥ 15.0 μM). Regarding aldehyde used for the derivatization of PABA, it is possible to tune up the particular activities and obtain derivatives with promising bioactivities.
