71942-38-6Relevant articles and documents
Synthesis, fluorescence properties, and antiproliferative potential of several 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives
Fu, Xiao-Bo,Wang, Xian-Fu,Chen, Jia-Nian,Wu, De-Wen,Li, Ting,Shen, Xing-Can,Qin, Jiang-Ke
, p. 18565 - 18584 (2015/11/11)
In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a-i and 6a-g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen species (ROS) level, suggesting that it may be a potent antitumor agent. In addition, compound 6g with very low cytotoxicity, demonstrated excellent fluorescence properties, which could be used as an effective fluorescence probe for biological imaging.
Synthesis and photoluminescent properties of two novel tripodal compounds containing coumarin moieties
Yu, Tianzhi,Zhang, Peng,Zhao, Yuling,Zhang, Hui,Meng, Jing,Fan, Duowang
scheme or table, p. 168 - 173 (2009/06/20)
Two novel tripodal compounds, tris[2-(7-diethylamino-coumarin-3-carboxamide)ethyl]amine (Tren-C1) and tris[2-(benzo[5,6]coumarin-3-carboxamide)ethyl]amine (Tren-C2), were synthesized and characterized. The UV-vis and fluorescence properties of Tren-C1 and Tren-C2 in solutions were investigated. These two compounds exhibited strong blue emission under ultraviolet light excitation. The maximal fluorescence emission occurred at about the level of 10-5 mol/L. The chromophore units in the tripodal compounds shown a little interaction in the ground state, while the interactions in the excited state was notable and which leads to a broad and bathochromic shift of the emission bands.