71948-62-4Relevant academic research and scientific papers
Synthesis and biological activity of 6-substituted mitosene analogues of the mitomycins
Casner,Remers,Bradner
, p. 921 - 926 (1985)
A series of 1-acetoxymitosene analogues, in which the substituent at C-6 was varied, was prepared by total synthesis and screened for activity against P388 leukemia in mice and induction of λ phase in Escherichia coli. Among the 6-substituents prepared, none was as effective as the methyl group in conferring biological activity. However, certain N-methylcarbamates were more active than the unsubstituted carbamates.
