71985-80-3

Basic information

• Product Name: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
• Synonyms: BIO-FARMA BF002150;4-CARBOXY-1-METHYL-PIPERIDINE HCL;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL;1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE;1-METHYLPIPERIDINO-4-CARBOXYLIC ACID HYDROCHLORIDE;1-METHYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE;TIMTEC-BB SBB003751;RARECHEM AH CK 0139
• CAS NO: 71985-80-3
• Molecular Formula: C₇H₁₄NO₂*Cl
• Molecular Weight: 179.64
• Product Categories: Piperidine
• Mol File: 71985-80-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 226-228°C (dec.)
• Boiling Point: 246.1 °C at 760 mmHg
• Flash Point: 102.6 °C
• Appearance: /
• Vapor Pressure: 0.00899mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(71985-80-3)
• EPA Substance Registry System: 1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE(71985-80-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-24/25-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 71985-80-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H

Upstream product

• 24252-37-7 ethyl 1-methylisonipecotate 
• 498-94-2 isonipecotic acid 
• 50-00-0 formaldehyd 

Downstream Products

• 874347-42-9 C₁₅H₂₄N₂O 
• 1160829-36-6 {4-[3-(1H-benzoimidazol-2-yl)-phenyl]-piperazin-1-yl}-(1-methyl-piperidin-4-yl)-methanone 
• 613678-03-8 (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone 
• 1579295-42-3 methyl 2-(4-(4-(4-(1-methylpiperidine-4-carboxamido)phenyl)butyl)phenyl)acetate 
• 1404055-20-4 (1R,4R)-4-((1,2-diphenylethoxy)carbonyl)-1-methyl-1-(2-oxo-2-phenylethyl)piperidinium bromide 
• 1404055-19-1 (E)-1,2-diphenylvinyl 1-methylpiperidine-4-carboxylate 
• 1404055-18-0 (1R,4R)-4-((1,2-diphenylethoxy)carbonyl)-1-methyl-1-(2-oxo-2-phenylethyl)piperidinium bromide 
• 1404055-25-9 (1S,4S)-4-((1,2-diphenylethoxy)carbonyl)-1-methyl-1-(2-oxo-2-phenylethyl)piperidinium bromide 
• 1404055-13-5 bis(3-fluorophenyl)methyl 1-methylpiperidine-4-carboxylate 
• 1404055-16-8 4-((bis(3-fluorophenyl)methoxy)carbonyl)-1-methyl-1-(2-oxo-2-(thiazol-2-yl)ethyl)piperidinium bromide 
• 1404055-15-7 4-((bis(3-fluorophenyl)methoxy)carbonyl)-1-methyl-1-(2-oxo-2-(thiophen-3-yl)ethyl)piperidinium bromide 

Relevant articles and documents

PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACE

The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processe

COMPOSITIONS AND METHODS OF SYNTHESIS OF PYRIDINOYLPIPERIDINE 5-HT1F AGONISTS

The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry

Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them

This invention relates to pyrrole derivatives of formula: STR1 in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]oxathiino[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrole ring-system and Hetis naphthyridinyl, pyridyl or quinolyl which is unsubstituted or substituted with halogen, (1 to 4 C) alkyl, (1 to 4 C) alkyloxy, (1 to 4 C) alkylthio or CF3 and R=(3 to 10 C) straight- or branched-chain alkenyl or alkyl which is unsubstituted or substituted with alkyloxy, alkylthio, (3 to 6 C) cycloalkyl, NH2, alkylamino, dialkylamino, alkylcarbonylamino, (in which the amino portion is optionally substituted with alkyl), 1- or 2-piperazinyl, piperidyl, piperidino, morpholino, pyrrolidinyl, 1-azetidinyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, (1-piperazinyl)carbonyl, piperidinocarbonyl, (1-pyrrolidinyl)carbonyl, phenyl, pyridyl, 1-imidazolyl, or alternatively R=2- or 3-pyrrolidinyl, 2-, 3- or 4-piperidyl, on the understanding that the alkyl radicals are straight- or branched-chain radicals and contain, except where specifically stated, 1 to 10 C, and that the piperazinyl, piperidino, piperidyl, pyrrolidinyl and azetidinyl radicals can be unsubstituted or substituted at any position with alkyl, alkylcarbonyl, benzyl or hydroxyalkyl, or can alternatively form a lactam group with the nitrogen atom of the ring, and, where they exist, their pharmaceutically acceptable salts and optical isomers, are useful as anxiolytics.