71989-17-8

Basic information

• Product Name: FMOC-ASN-ONP
• Synonyms: FMOC-ASPARAGINE-ONP;FMOC-ASN-ONP;FMOC-L-ASPARAGINE 4-NITROPHENYL ESTER;(S)-4-Nitrophenyl 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-aMino-4-oxobutanoate;Fmoc-L-Asn-ONp;Nα-Fmoc-L-asparagine 4-nitrophenyl ester≥ 98% (TLC)
• CAS NO: 71989-17-8
• Molecular Formula: C₂₅H₂₁N₃O₇
• Molecular Weight: 475.45
• Mol File: 71989-17-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 184-188 °C
• Boiling Point: 779°C at 760 mmHg
• Flash Point: 424.9°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 3.28E-24mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: 2-8°C
• PKA: 9.94±0.46(Predicted)
• CAS DataBase Reference: FMOC-ASN-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ASN-ONP(71989-17-8)
• EPA Substance Registry System: FMOC-ASN-ONP(71989-17-8)

Safety Data

• F: 8
• Hazardous Substances Data: 71989-17-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C25H21N3O7/c26-23(29)13-22(24(30)35-16-11-9-15(10-12-16)28(32)33)27-25(31)34-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H2,26,29)(H,27,31)

Upstream product

• 100-02-7 4-nitro-phenol 
• 71989-16-7 Fmoc-Asn-OH 

Relevant articles and documents

Peptide Synthesis. Part 2. Procedures for Solid-phase Synthesis using Nα-fluorenylmethoxycarbonylamino-acids on Polyamide Supports. Synthesis of Substance P and of Acyl Carrier Protein 65-74 Decapeptide

Use of base-labile Nα-9-fluorenylmethoxycarbonylamino-acids in combination with acid-labile t-butyl or p-alkoxybenzyl side-chain or carboxy-terminal (resin-linkage) protecting groups enables solid-phase peptide synthesis to be carried out under exceptionally mild reaction conditions.The repetitive and vigorous acidic treatments required in conventional synthesis are avoided.High-yield syntheses of a decapeptide and of an undecapeptide amide (Substance P) are described using this new combination of protecting groups on polyamide supports.