71989-28-1Relevant articles and documents
Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety
Zhu, Lunan,Zhu, Junchen,Sun, Xiaotong,Wu, Yaling,Wang, Huiying,Cheng, Lingping,Shen, Jiawei,Ke, Yanxiong
, p. 1080 - 1090 (2020/05/25)
Novel chiral selectors based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin connecting quinine (QN) or quinidine (QD) moiety were synthesized and immobilized on silica gel. Their chromatographic performances were investigated by comparing to the 3,5-dimethyl phenylcarbamoylated β-cyclodextrin (β-CD) chiral stationary phase (CSP) and 9-O-(tert-butylcarbamoyl)-QN-based CSP (QN-AX). Fmoc-protected amino acids, chiral drug cloprostenol (which has been successfully employed in veterinary medicine), and neutral chiral analytes were evaluated on CSPs, and the results showed that the novel CSPs characterized as both enantioseparation capabilities of CD-based CSP and QN/QD-based CSPs have broader application range than β-CD-based CSP or QN/QD-based CSPs. It was found that QN/QD moieties play a dominant role in the overall enantioseparation process of Fmoc-amino acids accompanied by the synergistic effect of β-CD moiety, which lead to the different enantioseparation of β-CD-QN-based CSP and β-CD-QD-based CSP. Furthermore, new CSPs retain extraordinary enantioseparation of cyclodextrin-based CSP for some neutral analytes on normal phase and even exhibit better enantioseparation than the corresponding β-CD-based CSP for certain samples.
Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders
Archilha, Marcos V. L. R.,Giroldo, Lilian,Kuznetsov, Aleksey E.,Meotti, Flávia C.,Pinatto-Botelho, Marcos F.,da Silva, Railmara P.,dos Santos, Alcindo A.
, p. 1239 - 1248 (2020/10/14)
This study describes a single step, high yield and purity, ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 × 107 M?1 s?1) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC50) = 23.07 μM) but not with superoxide anion radical or hydrogen peroxide without any cytotoxicity. These results show that this synthetically simple selenide reacts in a very efficient and specific way with the harmful pro-oxidant HOCl being a promising compound to be applied in oxidative inflammatory-related conditions.
Preparation method of methionine derivative corrosion inhibitor
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Paragraph 0019; 0020, (2016/10/31)
The invention discloses a preparation method of a methionine derivative corrosion inhibitor. The method comprises the following steps: synthesis of Fmoc-methionine: adding methionine and Fmoc-OSu into a DMF (N,N-dimethylformamide) solvent to react, and adding NaHCO3 to remove the solvent and residual amine compounds, thereby obtaining the product, wherein the yield is 78%; synthesis of Fmoc-methionine acyl chloride: adding the Fmoc-methionine into 25ml of CH2Cl2, and refluxing to react for 4 hours; and synthesis of Fmoc-methionine amide: after the acyl-chlorination reaction, directly adding into an equal mole of octadecylamine CH2Cl2 solution to obtain a yellow solid, and purifying the product by a chromatographic column separation process, wherein the eluting solution is composed of dichloromethane and methanol in a volume ratio of 20:1. According to the preparation method, the Fmoc- protective group is connected to the methionine molecule by amidation, and the adsorption site formed by the pi-electron-containing benzene ring enhances the adsorptivity of the corrosion inhibitor molecule. The hydrophobic long chain is connected to the methionine molecule to resist the attack of water molecules, so that a protective film is formed on the steel surface, thereby achieving the goal of corrosion inhibition.