71989-92-9 Usage
General Description
1-[3-(trifluoromethyl)phenyl]piperidin-4-ol, also known as Norfluoxetine, is a chemical compound that belongs to the class of piperidines. It is a secondary amine and a tertiary amine that contains a piperidine moiety with a trifluoromethyl-substituted phenyl group attached to it. Norfluoxetine is an active metabolite of the antidepressant drug fluoxetine, commonly known as Prozac, and it is formed in the body through the demethylation of fluoxetine. 1-[3-(trifluoromethyl)phenyl]piperidin-4-ol has been studied for its potential effects on the central nervous system and its role in the therapeutic actions of fluoxetine. It is also used as a reference standard in biochemical research and in the development of new pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 71989-92-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,9,8 and 9 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 71989-92:
(7*7)+(6*1)+(5*9)+(4*8)+(3*9)+(2*9)+(1*2)=179
179 % 10 = 9
So 71989-92-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H14F3NO/c13-12(14,15)9-2-1-3-10(8-9)16-6-4-11(17)5-7-16/h1-3,8,11,17H,4-7H2
71989-92-9Relevant articles and documents
Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides
Lloyd, Wayne,Reese, Colin B.,Song, Quanlai,Vandersteen, Anthony M.,Visintin, Cristina,Zhang, Pei-Zhou
, p. 165 - 176 (2007/10/03)
The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.
