71998-70-4Relevant academic research and scientific papers
Copper-catalyzed cross-coupling reactions of epoxides with gem-diborylmethane: access to γ-hydroxyl boronic esters
Ebrahim-Alkhalil, Ahmed,Zhang, Zhen-Qi,Gong, Tian-Jun,Su, Wei,Lu, Xiao-Yu,Xiao, Bin,Fu, Yao
, p. 4891 - 4893 (2016)
Herein, we describe a novel copper-catalyzed epoxide opening reaction with gem-diborylmethane. Aliphatic, aromatic epoxides as well as aziridines are converted to the corresponding γ-pinacolboronate alcohols or amines in moderate to excellent yields. This new reaction provides beneficial applications for classic epoxide substrates as well as interesting gem-diborylalkane reagents.
NOVEL RUTHENIUM COMPLEX AND METHOD FOR PREPARING METHANOL AND DIOL
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Paragraph 0093, (2015/09/23)
Provided is a method for preparing methanol and diol from cyclic carbonate, comprising: under a hydrogen atmosphere, in an organic solvent, and with the presence of a ruthenium complex (Ru(L)XYY') and an alkali, conducting a hydrogenation reduction reaction on the cyclic carbonate or polycarbonate to obtaib methanol and diol. Also provided is a ruthenium complex prepared from ruthenium and a tridentate amido diphosphine ligand. Also provided is a deuterated methanol and deuterated diol preparation method by substituting the hydrogen and ruthenium complex with deuterium.
Studies toward the synthesis of iejimalides A-D: Preparation of the C3-11 and C12-C24 fragments
Sabitha, Gowravaram,Gurumurthy,Yadav, Jhillu Singh
, p. 110 - 118 (2014/01/06)
The convergent synthesis of the C3-C11 and C12-C24 fragments of the iejimalides A-D is described. The C3-C11 fragment is obtained by a cross-metathesis reaction, while the C12-C24 fragment is derived from a Still-Gennari modified Horner-Wadsworth-Emmons o
Mechanistic investigation of the Candida albicans CCT 0776 stereoinversion system and application to obtain enantiopure secondary alcohols
Mantovani, Simone M.,Angolini, Celio F.F.,Marsaioli, Anita J.
experimental part, p. 2635 - 2638 (2010/03/30)
Phenylethanol deracemization with Candida albicans CCT 0776 whole cells yields the (R)-enantiomer in over 99% enantiomeric excess and 98% yield. The deracemization process involves, in the first step, a fast, highly (S)-selective oxidation (NADP and O2 dependent) and, in the second step, a slower partially (S)-selective reduction (NADH dependent) of the intermediate ketone. The process was extended to other 2-alkanols, 1,2-diols and 1,3-diols and, with the exception of 1,3-diol (unreactive), the enantiomeric excess and yield of the deracemization were about 99% and 62-98%, respectively.
