720-73-0

Basic information

• Product Name: 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: ART-CHEM-BB B025023;CHEMBRDG-BB 4400188;AKOS BAR-0006;AKOS B025023;4'-METHYL-1,1'-BIPHENYL-4-CARBOXYLIC ACID;4-METHYL-1,1-BIPHENYL-4-CARBOXYLIC ACID;4'-METHYLBIPHENYL-4-CARBOXYLIC ACID;4'-METHYL-4-BIPHENYLCARBOXYLIC ACID
• CAS NO: 720-73-0
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Product Categories: Biphenyl & Diphenyl ether
• Mol File: 720-73-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 252-253°C
• Boiling Point: 381.4±21.0 °C(Predicted)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• PKA: 4.23±0.10(Predicted)
• CAS DataBase Reference: 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID(720-73-0)
• EPA Substance Registry System: 4'-METHYLBIPHENYL-4-CARBOXYLIC ACID(720-73-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 720-73-0(Hazardous Substances Data)

Usage

Uses

The 4'-methyl-biphenyl-4-carboxylic acid exhibits the characteristic absorption bands of COOH and CH, groups. Photoproduct analysis, carried out by GC-MS, ETIR and GC-FTIR confirm three successive oxidation states of methyl suhstituents such as alcohol, aldehyde and carboxylic acids.

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 49742-56-5 methyl 4-(4-tolyl)benzoate 
• 787-70-2 4,4'-diphenic acid 
• 79757-92-9 (4'-methyl-[1,1'-biphenyl]-4-yl)methanol 
• 792-74-5 4,4'-biphenyldicarboxylic acid dimethyl ester 
• 106509-00-6 C₆₆H₆₆N₂O₁₄S₂ 

Relevant articles and documents

Preparation of metal-immobilized methacrylate-based monolithic columns for flow-through cross-coupling reactions

With the aim of developing efficient flow-through microreactors for high-throughput organic synthesis, in this work, microreactors were fabricated by chemically immobilizing palladium-, nickel-, iron-, and copper-based catalysts onto ligand-modified poly(glycidyl methacrylate-co-ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths, which were prepared inside a silicosteel tubing (10 cm long with an inner diameter of 1.0 mm) and modified with several ligands including 5-amino-1,10-phenanthroline (APHEN), iminodiacetic acid (IDA), and iminodimethyl phosphonic acid (IDP). The performance of the resulting microreactors in Suzuki?Miyaura cross-coupling reactions was evaluated, finding that the poly(GMA-co-EDMA) monolith chemically modified with 5-amino-1,10-phenanthroline as a binding site for the palladium catalyst provided an excellent flow-through performance, enabling highly efficient and rapid reactions with high product yields. Moreover, this monolithic microreactor maintained its good activity and efficiency during prolonged use.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.