72002-54-1

Basic information

• Product Name: D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid
• Synonyms: D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid;D-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carb;(R)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid;H-D-Tpi-OH, D-Tryptoline-3-carboxylic acid, D-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, D-1,2,3,4-Tetrahydro-b-carboline-3-carboxylic acid;1H-Pyrido[3,4-b]indole-3-carboxylicacid, 2,3,4,9-tetrahydro-, (3R)-
• CAS NO: 72002-54-1
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.239
• Mol File: 72002-54-1.mol

Chemical Properties

• Boiling Point: 485 °C at 760 mmHg
• Flash Point: 247.1 °C
• Appearance: /
• Density: 1.377
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid(72002-54-1)
• EPA Substance Registry System: D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid(72002-54-1)

Safety Data

• Hazardous Substances Data: 72002-54-1(Hazardous Substances Data)

Usage

Uses

Used in Neuropharmacology Research:
D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid is utilized as a subject of study in neuropharmacology for its potential role in neurological and psychiatric conditions such as Parkinson's disease and depression. D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid's impact on mood regulation and cognitive function is of particular interest, with ongoing research aimed at uncovering its therapeutic applications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid is considered as a potential therapeutic agent for the development of treatments targeting neurological disorders. Its presence in the brain and its effects on neurotransmission make it a promising candidate for further investigation and potential drug formulation.
Used in Diagnostic Tools:
D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid may also be employed in the development of diagnostic tools to assess neurological and psychiatric conditions. Its presence and levels in the brain could potentially serve as biomarkers for certain diseases, aiding in early detection and monitoring of treatment efficacy.

Upstream product

• 50-00-0 formaldehyd 
• 73-22-3 L-tryptophan 
• 36760-44-8 (R)-2-amino-3-(1H-indol-3-yl)propanoic acid hydrochloride 
• 153-94-6 D-tryptophan 
• 81075-61-8 (R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 

Downstream Products

• 80994-41-8 (R)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid ethyl ester 
• 98666-64-9 2-Phenethylsulfanylthiocarbonyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid 
• 148904-50-1 R(+)-1,2,3,4-tetrahydro-β-carboline-3-carboxy-N-cyclohexylamide 
• 123910-26-9 (R)-2-(tert-butoxycarbonyl)-2,3 ,4,9-tetrahydro-1 H-pyrido [3,4-b] indole-3-carboxylic acid 
• 96086-48-5 (3R)-2-benzyloxycarbonyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid 
• 617-88-9 2-Chloromethylfuran 
• 81075-61-8 (R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 
• 78538-74-6 FG 7142 
• 78538-80-4 N-ethyl β-carboline-3-carboxamide 
• 16253-64-8 methyl L-1,2,3,4-tetrahydro-β-carboline-3-carboxylate 

Relevant articles and documents

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Histone demethylating agents as potential S-adenosyl-l-methionine-competitors

Histone H3 methylation on K9 and/or K27 depends on histone lysine methyltransferases (KMTs). EZH2, one of the components of the PRC2 complex, catalyzes the trimethylation of histone H3K27, which is associated with transcriptional repression and tumor development. H3K9me3 mediated gene silencing may result from other KDMs such as G9a/GLP, SUV39H1-2, SETDB1, CCLD8 and RIZ1. Their disturbance leads to defective cell mitosis. It is therefore desirable to find small molecules that are able to decrease H3K9 and K27 tagging to reinitiate gene transcription. Most KDM inhibitors are still based on SAM co-factor competition/modulation. Herein, functional screening of a diversity library proved to be a useful tool for finding new specific KDM inhibitors; the use of SAM-based pharmacophoric models facilitated the understanding of their possible mechanism of action.

(R/S)-BINOL-α-phosphoryloxy enecarbamate-mediated and (R/S)-Titanium(IV) BINOLates-catalyzed enantioselective intramolecular heck/aza-diels-alder cycloaddition (IHADA): An expedient methodology

An (R/S)-titanium(IV) BINOLate-catalyzed highly enantioselective intramolecular Heck/aza-Diels-Alder cycloaddition (IHADA) cascade was developed to prepare tetrahydropyridoindoles (tHPs) and octahydropyrazinopyridoindoles (oHPPs) from in situ generated (R/S)-BINOL α-phosphoryloxy carbamate (αPPC2) in one pot. Chiral cooperativity between (R/S)-αPPC2 and (R/S)-titanium(IV) BINOLate was observed and successfully utilized for the construction of various tHPs (7 examples) and oHPPs (17 examples). Copyright

Some 3-carboxamides of β-carboline and tetrahydro-β-carboline

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