72005-58-4 Usage
Originator
Vadocaine hydrochloride ,ZYF Pharm Chemical
Manufacturing Process
3-Chloro-4',6'-dimethyl-o-propananisidide was prepared by using 92.8 g
(0.615 mol) 4,6-dimethyl-o-anisidine and 86 g (0.68 mol) of 3-chloropropionyl
chloride, melting point 123-125°C. A mixture containing 40 g (0.165 mol) of
3-chloro-4',6'-dimethyl-o-propananisidide, 54.3 g of 3-methyl piperidine, and
330 ml of anhydrous benzene was heated for 72 hours at 65°C. 47.7 g (84.5%) of N-(2-methoxy-4,6-dimethylphenyl)-2-methyl-1-
piperidinepropanamide hydrochloride was obtained by deposition of product in
anhydrous acetone saturated with hydrogen chloride; melting point 192-193°C
(crystallization from a mixture isopropanol-acetone).
Therapeutic Function
Antitussive, Local anesthetic
Check Digit Verification of cas no
The CAS Registry Mumber 72005-58-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,0,0 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 72005-58:
(7*7)+(6*2)+(5*0)+(4*0)+(3*5)+(2*5)+(1*8)=94
94 % 10 = 4
So 72005-58-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H28N2O2/c1-13-11-14(2)18(16(12-13)22-4)19-17(21)8-10-20-9-6-5-7-15(20)3/h11-12,15H,5-10H2,1-4H3,(H,19,21)
72005-58-4Relevant academic research and scientific papers
Antitussive anilides
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, (2008/06/13)
The invention relates to novel antitussive anilides and non-toxic acid addition salts thereof. These novel compounds have the general formula STR1 wherein n is an integer from 2 to 3, and substituents R1 and R2 are lower alkyl groups
