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Urea, 1-(3-(4-oxo-2-phenyl-3,4-dihydro-3-quinazolinyl)propionyl)-3-(p-tolyl)-2-thio- is a complex organic compound with the molecular formula C24H22N4O3S. It is a derivative of urea, featuring a quinazolinyl moiety, which is a heterocyclic aromatic ring system. The compound has a 4-oxo-2-phenyl-3,4-dihydro-3-quinazolinyl group attached to a propionyl chain, which in turn is connected to a urea group. Additionally, it contains a p-tolyl (para-methylphenyl) group and a thiourea functional group. This chemical is characterized by its potential applications in pharmaceuticals, particularly as an inhibitor of dipeptidyl peptidase-4 (DPP-4), an enzyme involved in the regulation of glucose levels in the body. The compound's structure allows it to interact with the enzyme, thereby modulating its activity and potentially contributing to the treatment of type 2 diabetes.

72045-67-1

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72045-67-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72045-67-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,0,4 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72045-67:
(7*7)+(6*2)+(5*0)+(4*4)+(3*5)+(2*6)+(1*7)=111
111 % 10 = 1
So 72045-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C25H22N4O2S/c1-17-11-13-19(14-12-17)26-25(32)28-22(30)15-16-29-23(18-7-3-2-4-8-18)27-21-10-6-5-9-20(21)24(29)31/h2-14H,15-16H2,1H3,(H2,26,28,30,32)

72045-67-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(4-methylphenyl)carbamothioyl]-3-(4-oxo-2-phenylquinazolin-3-yl)propanamide

1.2 Other means of identification

Product number -
Other names 1-(3-(4-Oxo-2-phenyl-3,4-dihydro-3-quinazolinyl)propionyl)-3-(p-tolyl)-2-thiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72045-67-1 SDS

72045-67-1Upstream product

72045-67-1Downstream Products

72045-67-1Relevant academic research and scientific papers

Synthesis of N-aryl-N'-[2-phenyl-3-quinazolino(3H)-4-one] acylthiourea derivatives as anticonvulsants

Misra,Pandey,Dua

, p. 161 - 167 (2007/10/09)

By the reaction of [2-phenyl-3-quinazolino(3H)-4-one] acyl isothiocyanates and appropriate aryl amines in acetone, 24 new compounds, having a substituted thiourea grouping at the 3-position of the quinazolone moiety, were prepared. All compounds, except two, showed different degrees of protection agsinst pentetrazol induced seizure test on albino mice. While studying the effect of structural variation no definite pattern could be observed due to variations in 1-aryl moiety, but it was generally noticed that the branching or lengthening of 3-acyl chain either diminishes or does not effect the activity.

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