72045-77-3Relevant academic research and scientific papers
Synthesis of N-aryl-N'-[2-phenyl-3-quinazolino(3H)-4-one] acylthiourea derivatives as anticonvulsants
Misra,Pandey,Dua
, p. 161 - 167 (2007/10/09)
By the reaction of [2-phenyl-3-quinazolino(3H)-4-one] acyl isothiocyanates and appropriate aryl amines in acetone, 24 new compounds, having a substituted thiourea grouping at the 3-position of the quinazolone moiety, were prepared. All compounds, except two, showed different degrees of protection agsinst pentetrazol induced seizure test on albino mice. While studying the effect of structural variation no definite pattern could be observed due to variations in 1-aryl moiety, but it was generally noticed that the branching or lengthening of 3-acyl chain either diminishes or does not effect the activity.
