7205-88-1

Upstream product

• 701-57-5 1-methylthio-4-nitro-benzene 
• 74-97-5 chlorobromomethane 
• 1849-36-1 para-nitrobenzenethiol 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 116387-96-3 1-(4-nitrophenylthiomethyl)-4-pyridone 
• 27691-43-6 1-(benzylsulphanyl)-4-Nitrobenzene 
• 17387-48-3 bis(1'-mercapto-4'-nitrophenyl)methane 
• 65325-70-4 1-((fluoromethyl)sulfinyl)-4-nitrobenzene 
• 97715-01-0 triphenylphosphonium-(p-nitrophenylthio)methylide 
• 65325-66-8 1-[(fluoromethyl)sulfanyl]-4-nitrobenzene 
• 134281-48-4 4-nitrophenylthiomethyl cyclohexanecarboxylate 

Relevant academic research and scientific papers

Monofluoromethyl-Substituted Sulfonium Ylides: Electrophilic Monofluoromethylating Reagents with Broad Substrate Scopes

Two electrophilic monofluoromethylating reagents, monofluoromethyl(phenyl)sulfonium bis(carbomethoxy)methylide (3 a) and monofluoromethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (3 b), and their reactions under mild conditions with a variety of nucleophiles, such as alcohols and malonate derivatives, sulfonic and carboxylic acids, phenols, amides, and N heteroarenes, are described. Mechanistic studies with deuterated reagents [D2]3 a/[D2]3 b suggest that these monofluoromethylation reactions proceed through an electrophilic substitution pathway.

2-Sulfinyl Oxetanes: Synthesis, Stability and Reactivity

The synthesis of 2-sulfinyl oxetanes is described by a C-C bond-forming cyclisation strategy. Oxetanes bearing electron-poor aryl sulfoxides are shown to be viable targets using this strategy. We report investigations into the sulfoxide magnesium exchange

Monomethylation of Aromatic Rings by Friedel-Crafts Reaction with Chloromethyl Sulfide

A novel method for the introduction of a methyl group into aromatic rings is described.Friedel-Crafts reactions of ethyl α-(chloromethylthio)acetate (3k) and α-chloromethylthio-γ-butyrolactone (3m) with an arene in the presence of stannic chloride gave ethyl α-(arylmethylthio)acetate (6) and α-arylmethylthio-γ-butyrolactone (7), respectively, which were easily converted to the corresponding methylated arene (8) by reductive desulfurization with Raney nickel or zinc dust-acetic acid.Keywords - monomethylation; ethyl α-(chloromethylthio)acetate Friedel-Crafts reaction; α-chloromethylthio-γ-butyrolactone Friedel-Crafts reaction; ethyl α-(arylmethylthio)acetate; α-arylmethylthio-γ-butyrolactone; methylated arene; reductive desulfurization; Raney nickel; zinc dust-acetic acid

SYNTHESIS AND CONFIGURATIONAL STUDIES OF ARYL CYCLOPROPYL SULFONES

The cycloaddition of arylthiocarbenes to styrene gave stereospecifically cis-1-(arylthio)-2-phenylcyclopropanes, which were subsequently oxidized to the corresponding sulfones.The cyclopropanation of α,β-unsaturated sulfones with dimethylsulfonium methylide yielded stereoselectively trans-1-(arylsulfonyl)-2-arylcyclopropanes.The configurational assignments of these compounds have been arrived at on the basis of IR and PMR spectral data.Chemical shifts for ring protons and other substituents reveal that all the substituents tend to cause protons cis to them to appear at higher fields than those trans to them.This has been used as a criterion to distinguish between cis and trans aryl cyclopropyl sulfones.