72064-79-0

Basic information

• Product Name: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate
• Synonyms: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate;Prednisolone valerate acetate;Acepreval;Lidomex;Prednival 21-acetate;Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-acetate 17-valerate (7CI);Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-[(1-oxopentyl)oxy]-, (11b)- (9CI);11-beta,17-alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-valer
• CAS NO: 72064-79-0
• Molecular Formula: C₂₈H₃₈O₇
• Molecular Weight: 486.59712
• EINECS: 276-312-8
• Product Categories: Steroids
• Mol File: 72064-79-0.mol

Chemical Properties

• Boiling Point: 502.49°C (rough estimate)
• Flash Point: 196.3 °C
• Appearance: /
• Density: 1.1134 (rough estimate)
• Vapor Pressure: 1.78E-17mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• PKA: 14.05±0.70(Predicted)
• CAS DataBase Reference: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate(CAS DataBase Reference)
• NIST Chemistry Reference: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate(72064-79-0)
• EPA Substance Registry System: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate(72064-79-0)

Safety Data

• Hazardous Substances Data: 72064-79-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Prednisolone 21-Acetate 17-Valerate is used as an anti-inflammatory and immunosuppressive agent for the treatment of various conditions, including autoimmune diseases, allergic reactions, and inflammation-related disorders. Its potent effects help in reducing inflammation and suppressing the immune system, providing relief from the symptoms and progression of these conditions.
Used in Cancer Therapy:
In the field of oncology, Prednisolone 21-Acetate 17-Valerate is utilized in a multifunctional nanoemulsion platform for imaging-guided therapy. This innovative approach allows for the targeted delivery of the compound to cancer cells, enhancing its therapeutic efficacy and reducing potential side effects. 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-valerate's anti-inflammatory properties also contribute to the management of cancer-related inflammation and pain.
Used in Drug Delivery Systems:
To improve the bioavailability and targeted delivery of Prednisolone 21-Acetate 17-Valerate, various drug delivery systems have been developed. These systems, such as nanoparticles and liposomes, enable the controlled release of the compound, ensuring its optimal concentration at the site of action and minimizing potential side effects. This advancement in drug delivery technology enhances the therapeutic outcomes of Prednisolone 21-Acetate 17-Valerate in various medical applications.

Safety Profile

Poison by subcutaneous route.Moderately toxic by other routes. An experimentalteratogen. Other experimental reproductive effects.

InChI:InChI=1/C28H38O7/c1-5-6-7-24(33)35-28(23(32)16-34-17(2)29)13-11-21-20-9-8-18-14-19(30)10-12-26(18,3)25(20)22(31)15-27(21,28)4/h10,12,14,20-22,25,31H,5-9,11,13,15-16H2,1-4H3/t20-,21-,22-,25+,26-,27-,28-/m0/s1