720666-45-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-2-chloro-5-methoxypyridine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its antimalarial, antifungal, and antibacterial properties. It serves as a valuable building block in drug discovery research and development, contributing to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Amino-2-chloro-5-methoxypyridine is utilized as a precursor in the production of agrochemicals, capitalizing on its ability to combat a range of pests and diseases in agriculture. Its synthesis contributes to the development of effective and targeted crop protection products.

InChI:InChI=1/C6H7ClN2O/c1-10-4-2-5(8)6(7)9-3-4/h2-3H,8H2,1H3

Upstream product

• 64436-92-6 3-amino-5-methoxypyridine 

Downstream Products

• 768360-27-6 (2-chloro-5-methoxy-pyridin-3-yl)-[7-(2,4-dimethoxy-benzyloxy)-5-isopropoxy-quinazolin-4-yl]-amine 
• 959615-59-9 7-methoxy-1,5-naphthyridin-2(1H)-one 
• 959615-58-8 ethyl (2E)-3-(3-amino-5-methoxypyridin-2-yl)acrylate 

Relevant academic research and scientific papers

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and physical properties suitable for oral dosing were achieved within this series: 23d and 42 were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.

QUINOLINE DERIVATIVES AND USE THEREOF AS ANTITUMOR AGENTS

The invention concerns quinoline derivatives of Formula I: wherein Z is an O, S, SO, SO2, N(R2) or C(R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-6C)alkyl, m is 1, 2 or 3, each R1 group is selected from halogeno, (1-6C)alkyl, (1-6C)alkoxy and any of the other meanings defined in the description, Ra is hydrogen or halogeno, Rb is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy, Rc is (1-6C)alkoxy and Rd is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy, or Rb and Rc together or Rc and Rd together form a (1-3C) alkylenedioxy group, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I ) wherein Z is an O, S, SO, SO2, N(R2) or C(R2)(R3) group wherein each R2 or R3 group is hydrogen or (1-6C)alkyl, m is 1, 2 or 3