720692-44-4Relevant academic research and scientific papers
The discovery of the benzazepine class of histamine H3 receptor antagonists
Wilson, David M.,Apps, James,Bailey, Nicholas,Bamford, Mark J.,Beresford, Isabel J.,Briggs, Michael A.,Calver, Andrew R.,Crook, Barry,Davis, Robert P.,Davis, Susannah,Dean, David K.,Harris, Leanne,Heightman, Tom D.,Panchal, Terry,Parr, Christopher A.,Quashie, Nigel,Steadman, Jon G.A.,Schogger, Joanne,Sehmi, Sanjeet S.,Stean, Tania O.,Takle, Andrew K.,Trail, Brenda K.,White, Trevor,Witherington, Jason,Worby, Angela,Medhurst, Andrew D.
, p. 6897 - 6901 (2014/01/06)
This Letter describes the discovery of a novel series of H3 receptor antagonists. The initial medicinal chemistry strategy focused on deconstructing and simplifying an early screening hit which rapidly led to the discovery of a novel series of
3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS
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Page/Page column 15-16, (2010/02/15)
The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
TERTRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS
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Page/Page column 24, (2010/02/14)
The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
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Page/Page column 17, (2010/02/07)
The present invention relates to benzazepine derivatives of formula ( I ) wherein: R1 represents -C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
