720702-43-2Relevant academic research and scientific papers
Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1 H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombo
Xiong, Yifeng,Teegarden, Bradley R.,Choi, Jin-Sun Karoline,Strah-Pleynet, Sonja,Decaire, Marc,Jayakumar, Honnappa,Dosa, Peter I.,Casper, Martin D.,Pham, Lan,Feichtinger, Konrad,Ullman, Brett,Adams, John,Yuskin, Diane,Frazer, John,Morgan, Michael,Sadeque, Abu,Chen, Weichao,Webb, Robert R.,Connolly, Daniel T.,Semple, Graeme,Al-Shamma, Hussien
experimental part, p. 4412 - 4421 (2010/08/06)
Serotonin, which is stored in platelets and is released during thrombosis, activates platelets via the 5-HT2A receptor. 5-HT2A receptor inverse agonists thus represent a potential new class of antithrombotic agents. Our medicinal pro
3-Phenyl-pyrazole derivatives as modulators of the 5-HT2a serotonin receptor useful for the treatment of disorders related thereto
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Page/Page column 62, (2010/11/28)
The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are di
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO
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, (2010/02/10)
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
DIARYLAMINE AND ARYLHETEROARYLAMINE PYRAZOLE DERIVATIVES AS MODULATORS OF 5HT2A
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, (2010/02/07)
One aspect of the present invention relates to certain diarylamine and arylheteroarylamine pyrazole derivatives of Formula (A) and pharmaceutical compositions that modulate the activity of the human 5HT2A serotonin receptor. Compounds and pharmaceutical c
