72083-16-0

Upstream product

• 72083-15-9 (2-methoxy-5-trifluoromethyl-phenyl)-phenyl-methanone 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 92381-17-4 O-(4-trifluoromethylphenyl)hydroxylamine 
• 108-86-1 bromobenzene 
• 611-73-4 Benzoylformic acid 
• 63878-78-4 1-(prop-2-yn-1-yloxy)-4-(trifluoromethyl)benzene 
• 402-45-9 4-hydroxybenzotrifluoride 
• 591-50-4 iodobenzene 

Downstream Products

• 72089-85-1 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide 
• 72082-67-8 4-{[1-(2-Hydroxy-5-trifluoromethyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyric acid 

Relevant academic research and scientific papers

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

RhIII-Catalyzed Decarboxylative o-Acylation of Arenes Bearing an Oxidizing Directing Group

Here in we report, rhodium(III)-catalyzed decarboxylative acylation of arenes using α-oxocarboxylic acids as acyl surrogate. In this strategy, O–NHAc group act as an autocleavable oxidizing directing group (ODGauto), thus giving rise to ortho-acylated phenols in moderate to good yields. Mechanistic studies provided strong support for a kinetically relevant C–H bond activation. According to the best of our knowledge, this is the first report of Rhodium catalyzed decarboxylative acylation.

Acylation of Csp2-H bond with acyl sources derived from alkynes: Rh-Cu bimetallic catalyzed CC bond cleavage

A Rh-Cu bimetallic catalyzed o-acylation of acyloxacetamide with alkynes has been described. This transformation provides a novel, concise way to synthesize ortho-acylphenols using functionalized alkynes as acylating reagents. Mechanistic studies revealed a Rh-Cu relay process, in which O2 plays a critical role for the formation of carbonyl compounds.

PPAR MODULATORS

The present invention is directed to a compound of formula I, or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.