72090-73-4Relevant academic research and scientific papers
Decarboxylative (4+1) Oxidative Annulation of Malonate Monoesters with 2-Vinylpyridine Derivatives
Tang, Shan,Gao, Xinlong,Lei, Aiwen
supporting information, p. 2878 - 2882 (2016/09/16)
A novel N-iodosuccinimide-mediated decarboxylative (4+1) oxidative annulation between 2-vinylpyridine derivatives and malonate monoesters was developed. It offers a new way to construct indolizine derivatives by utilizing malonate monoesters as a C1unit. The alkyl 2,2-diiodoacetate was found to be the active reaction intermediate during the transformation. (Figure presented.).
(AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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Paragraph 0078, (2013/08/15)
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. The present invention relates to (aza)indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, 0 to 2 of X1, X2, X3 and X4 are a nitrogen atom and the others are CR1; one of T1 and T2 represents cyano and the other represents a group represented by the following formula (A), with the proviso that when T1 is cyano, at least one of X1 to X4 is a nitrogen atom; R1 independently represents a hydrogen atom, a halogen atom, a hydroxy group, C1-6 alkyl, C1-6 alkoxy or the like; ring U represents a benzene ring or the like; m represents integral number from 0 to 2; R2 independently represents a fluorine atom, a hydroxy group or the like.
NITROOLEFINS. I. A NEW AND CONVENIENT ACCESS TO INDOLIZINES AND PYRAZOLOPYRIDINES USING 1-NITRO-2-(PHENYLTHIO>ETHYLENE
Tominaga, Yoshinori,Ichihara, Yuichi,Hosomi, Akira
, p. 2345 - 2348 (2007/10/02)
1-Nitro-2-(phenylthio)ethylene (1) reacts with a variety of N-ylides and N-imines (pyridinium, isoquinolinium, quinolinium, phthalazinium N-ylides and N-imines) in the presence of triethylamine to give the corresponding fused pyrrole and pyrazole derivatives (indolizines, pyrroloisoquinoline, pyrrolophthalazine, pyrazolopyridine, pyrazoloquinoline, and pyrazoloisoquinoline) along with the corresponding 1-nitropyrrolopyridines and 1-nitropyrazolopyridines, respectively, in moderate yields.
Synthesis of 2-Methylthioindolizine-3-carbonitriles Using Nitro Ketene Dithioacetal
Tominaga, Yoshinori,Shiroshita, Yoshihide,Hosomi, Akira
, p. 1745 - 1749 (2007/10/02)
The reaction of 1-cyanomethylpyridinium chloride or bromide, 1a-i, with 1,1-bis(methylthio)-2-nitroethylene (2) in the presence of triethylamine as a base in ethanol gave the corresponding 2-methylthioindolizine-3-carbonitrile 3 and 2-methyl-thio-1-nitroindolizine-3-carbonitrile 4 in good yields, respectively.Compounds 3a,f were key intermediates for the synthesis of cyclazine derivatives.
The 1,3-Dipolar Cycloaddition Reactions of Heteroaromatic Dicyanomethylides with Phenylsulfinylethene and Bis(trimethylsilyl)ethyne: Synthesis of 1,2-Unsunstituted 3-Cyanoindolizines
Matsumoto, Kiyoshi,Uchida, Takane,Ikemi, Yukio,Tanaka, Toshio,Asahi, Momoyo,et al.
, p. 3645 - 3654 (2007/10/02)
Pyridinium and diazinium dicycanomethylides underwent 1,3-dipolar cycloaddition-extrusion reactions with phenylsulfinylethene, producing the corresponding 3-cyanoindolizines in moderate to good yields. 1,3-Dipolar cycloadditions of these ylides with bis(t
1,3-DIPOLAR CYCLOADDITION OF PYRIDINIUM AND DIAZINIUM DICYANOMETHYLIDS WITH BIS(TRIMETHYLSILYL)ACETYLENE: SYNTHESIS OF TRIMETHYLSILYL SUBSTITUTED INDOLIZINES AND BIS(TRIMETHYLSILYL)ACETYLENE AS AN ACETYLENE EQUIVALENT IN 1,3-DIPOLAR CYCLOADDITION
Ikemi, Yukio,Matsumoto, Kiyoshi,Uchida, Takane
, p. 1009 - 1012 (2007/10/02)
Cycloaddition reactions of pyridinium and diazinium dicyanomethylids with bis(trimethylsilyl)acetylene give either the corresponding 1,2-di(trimethylsilyl)-3-cyanoindolizines or the mixtures of these and 1-(trimethylsilyl)-3-cyanoindolizines depending on
