72093-14-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3,6-dimethylpyridine is used as a reactant in the preparation of resorcinol N-aryl amide compounds, which are pyruvate dehydrogenase kinase inhibitors. These inhibitors play a crucial role in the development of drugs targeting metabolic pathways associated with various diseases, including cancer and neurodegenerative disorders. 2-Chloro-3,6-dimethylpyridine's reactivity and structural features enable the synthesis of bioactive molecules with potential therapeutic applications.

InChI:InChI=1/C7H8ClN/c1-5-3-4-6(2)9-7(5)8/h3-4H,1-2H3

Upstream product

• 125014-90-6 Nitrile of 2-Methyl-2-chloro-5-oxohexanoic Acid 
• 18368-76-8 2 chloro-3-methylpyridine 
• 74-88-4 methyl iodide 
• 108-01-0 2-(N,N-dimethylamino)ethanol 

Downstream Products

• 68164-77-2 3,6-dimethylpyridine-2-carbonitrile 

Relevant academic research and scientific papers

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

SUBSTITUTED AMINOPYRIDINES AND USES THEREOF

This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Pyridylthio-acylanilide herbicides

Novel herbicidally active pyridylthio-acylanilides of the formula STR1 in which R1, R2 and R3, independently of one another, represent hydrogen, halogen, cyano or trifluoromethyl or alkyl, alkoxy and alkylthio having 1 to 4 carbon atoms in each case, R4 represents halogen, methyl or methoxy, n represents a number 0, 1 or 2, z represents the group (Ia) STR2 or the group (Ib) STR3 where X represents oxygen, sulphur, an N--R10 or N--O--R11 group, or X and Rg tpgether represent the STR4 radical, and the other radicals can have various meanings. Intermediates of the formulae STR5 are also new.

HALOGEN-SUBSTITUITED PYRIDINES. 3.* CYCLIZATION OF ADDUCTS OF α,α-DICHLOROPROPIONITRILE WITH ACRYLIC DERIVATIVES TO CHLOROPYRIDINES

Reactions of α,α-dichloropropionitrile with acrylic derivatives in the presence of Cu2Cl2 gave a series of substituted 2,4-dichloro- and 2-chloro-5-oxoalkanonitriles.Their cyclization to chloropyridines has been studied.