721-95-9Relevant academic research and scientific papers
Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2 H-Chromenes
Cervi, Aymeric,Vo, Yen,Chai, Christina L. L.,Banwell, Martin G.,Lan, Ping,Willis, Anthony C.
, p. 178 - 198 (2020/12/22)
Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system 56, and their Au(I)-catalyzed cyclization (intramolecular hydroarylation) to give the corresponding coumarins (e.g., 1). Simple syntheses of natural products such as ayapin (144) and scoparone (145) have been realized by such means, and the first of these subject to single-crystal X-ray analysis. A related process is described for the conversion of propargyl ethers such as 156 into the isomeric 2H-chromene precocene I (159), a naturally occurring inhibitor of juvenile hormone biosynthesis.
Synthesis of Bis(propynoyloxy) Aromatics
Wehler, Jon R.,Feld, William A.
, p. 142 - 143 (2007/10/02)
Ten bis(propynoyloxy) aromatics were prepared, in yields ranging from 28percent to 68percent, from propynoyl chloride and the disodium salt of the corresponding dihydroxy aromatic.The structures of these ethynyl compounds were confirmed by IR, (1)H NMR, and DSC.
