72118-68-4

Upstream product

• 72179-14-7 3-Chloro-4-dimethylaminomethylene-1,4-dihydroisoquinoline 
• 17507-05-0 1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 
• 72118-85-5 3-chloro-1-phenyl-isoquinoline-4-carbonitrile 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 72179-25-0 3-Chloro-1-(3-nitrophenyl)-isoquinoline-4-aldehyde 
• 72118-88-8 3-Chloro-1-phenyl-isoquinoline-4-carboxylic acid 
• 72118-69-5 3-(4-methyl-piperazin-1-yl)-1-phenyl-isoquinoline-4-carbaldehyde 
• 1202021-94-0 1-phenyl-3-trimethylsilylethynyl-4-isoquinoline carboxaldehyde 

Relevant academic research and scientific papers

Multicomponent approach for the synthesis of phenanthridine and acridine ring systems via the coupling of fischer carbene complexes with hetero-aromatic o-alkynyl carbonyl derivatives

A one-pot multicomponent synthesis of phenanthridine and acridine derivatives is described. This method includes the in situ generation of furo[3,4-c]isoquinoline and furo[3,4-b]quinoline intermediates by the coupling of heteroaromatic o-alkynyl carbonyl derivatives with Fischer carbene complexes and subsequent trapping of these intermediates by suitable dienophiles. Georg Thieme Verlag Stuttgart - New York.

Tandem generation and trapping of furo[3, 4-c]isoquinoline intermediates leading to the synthesis of phenanthridine ring systems

One pot three component coupling of 3-alkynyl-4-isoquinoline carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of phenanthridine ring system has been investigated. This reaction involves the generation of furo[3,

Synthesis and Reactions of Isoquinoline Derivatives III. Synthesis and Reactions of 3,4-Dihalogeno-1-phenylisoquinolines

Reaction of 1-phenyl-1,4-dihydro-3(2H)isoquinolinone (1) with phosphorus pentahalides as well as a two-step procedure involving a Vilsmeier-Haack acylation of 1 followed by oxidative cleavage with sodium hypohalites make 3,4-dihalogeno-1-phenylisoquinolines easily available.

Synthesis and Reactions of Isoquinoline Derivatives II. Synthesis of 3-Chloroisoquinoline-4-aldehydes

1-Aryl-substituted 1,4-dihydro-3(2H)isoquinolinones 1 are easily converted to 1-aryl-3-chloroisoquinoline-4-aldehydes 3 by a two-step procedure involving a Vilsmeier-Haack reaction followed by subsequent oxidation with potassium permanganate under acidic

Isoquinoline aldehydes

Isoquinoline-4-aldehydes of the formula STR1 in which X denotes bromine or chlorine, R1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydr