72131-15-8

Upstream product

• 7765-82-4 3-chloro-2-ethyl-benzo[d]isothiazolium; chloride 
• 121-69-7 N,N-dimethyl-aniline 
• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 100-68-5 methyl-phenyl-thioether 

Relevant academic research and scientific papers

Preparation of Thioanisole Biscarbanion and C-H Lithiation/Annulation Reactions for the Access of Five-Membered Heterocycles

The synthesis, isolation, and X-ray structure of a thioanisole-based trilithium complex are reported. On the basis of the double-lithiation strategy, two novel synthetic methodologies have been developed under mild reaction conditions (room temperature): (1) reactions of lithiated thioanisoles with nitriles give benzoisothiazoles via a [3 + 2]-type of approach with two new bond formations and (2) formation of benzothiophenes from thioanisoles and amides through a [4 + 1] pattern forming 4 new chemical bonds.

Preparation method of benzisothiazole derivative

The invention discloses a preparation method of a benzisothiazole derivative. The method comprises the following steps that a benzyl disulfide (I), N,N,N',N'-tetramethylethylenediamine (II) and a C1-C10 lithium alkylide (III) normal hexane solution are sequentially added into a solvent, reaction, filtering and drying are performed to obtain di-lithium compound white powder, the di-lithium compound and a cyano compound (V) are subjected to a reaction under the room temperature, and the benzisothiazole derivative (VI) is obtained. The method has the advantages that operation is easy, reaction raw materials and reaction reagents are easy to obtain, product substituent groups have diversified types, and the yield is high.