721431-18-1 Usage
Uses
Used in Biochemical Research:
15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a biotinylation reagent for the modification of amine-containing molecules in biochemical research. The extended PEG spacer arm allows for better accessibility to the protein binding pocket, enhancing the efficiency of biotinylation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a component in the development of drug delivery systems. The biotinylated molecules can be conjugated to targeting ligands, enabling selective delivery of therapeutic agents to specific cells or tissues.
Used in Diagnostic Applications:
In the medical diagnostics industry, 15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a key component in the development of diagnostic tools. The biotinylated molecules can be employed in the creation of assays and tests that detect specific biomarkers, providing valuable information for disease diagnosis and monitoring.
Used in Protein Engineering:
In the field of protein engineering, 15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as a biotinylation agent for the modification of proteins. The biotinylated proteins can be employed in various applications, such as affinity purification, immobilization on solid supports, and the creation of biosensors.
Used in Cosmetics Industry:
In the cosmetics industry, 15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID is used as an ingredient in the formulation of skincare products. The biotinylated molecules can enhance the delivery of active ingredients to the skin, improving the efficacy of the products and providing additional benefits, such as increased hydration and improved skin texture.
Check Digit Verification of cas no
The CAS Registry Mumber 721431-18-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,1,4,3 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 721431-18:
(8*7)+(7*2)+(6*1)+(5*4)+(4*3)+(3*1)+(2*1)+(1*8)=121
121 % 10 = 1
So 721431-18-1 is a valid CAS Registry Number.
721431-18-1Relevant articles and documents
Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition
Zhu, Tian-Yu,Wu, Xiu-Tao,Chen, Chen,Liu, Xiao-Qin,Zhu, Li,Luo, Jian-Guang,Kong, Ling-Yi
supporting information, p. 449 - 456 (2022/02/14)
Harringtonolide (HO, 1) is a bioactive diterpenoid tropone isolated from Cephalotaxus harringtonia with antiproliferation activity. Until now there have been no reports to elucidate its anticancer mechanism. Herein we report the synthesis of HO-derived probes (10, 11, and 12) to identify the possible target of HO. As a result, the application of a novel photoaffinity alkyne-tagged probe from HO (compound 12) showed direct engagement between HO and receptor for activated C kinase 1 (RACK1). Furthermore, HO could suppress the epithelial-mesenchymal transition (EMT) process and inhibit activation of the FAK/Src/STAT3 signaling pathway in A375 cells. This study provides a groundwork for HO as an effective antitumor agent that targets RACK1 to suppress cancer cell migration.
