721450-86-8

Upstream product

• 75-34-3 1,1-dichloroethane 
• 13865-19-5 4-oxobutanoic acid methyl ester 
• 53312-79-1 3-amino-4-chloro-benzonitrile 
• 4220-66-0 methyl 4,4-dimethoxybutanoate 

Downstream Products

• 721450-87-9 4-chloro-3-(N-methyl-N-(4-butyric acid methyl ester)-amino)-benzonitrile 

Relevant academic research and scientific papers

Methods of treating diseases responsive to Induction of Apoptosis

The present invention pertains to a method of treating, preventing or ameliorating a disease responsive to induction of the caspase cascade in an animal, comprising administering to the animal a compound which binds specifically to a Tail Interacting Prot

3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.