721455-06-7Relevant academic research and scientific papers
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents
Cherney, Robert J.,Mo, Ruowei,Meyer, Dayton T.,Wang, Li,Yao, Wenqing,Wasserman, Zelda R.,Liu, Rui-Qin,Covington, Maryanne B.,Tortorella, Micky D.,Arner, Elizabeth C.,Qian, Mingxin,Christ, David D.,Trzaskos, James M.,Newton, Robert C.,Magolda, Ron L.,Decicco, Carl P.
, p. 1297 - 1300 (2003)
Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The N-methanesulfonyl piperidine 23 and the N-trifluoroacetyl azetidine 26 were the most potent aggrecanase inhibitors both having an IC50=3 nM while
4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page 37; 21, (2010/02/07)
3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
