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7215-07-8

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7215-07-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7215-07-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,1 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7215-07:
(6*7)+(5*2)+(4*1)+(3*5)+(2*0)+(1*7)=78
78 % 10 = 8
So 7215-07-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO/c1-12-10-4-2-8(3-5-10)9-6-11-7-9/h2-5,9,11H,6-7H2,1H3

7215-07-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methoxyphenyl)azetidine

1.2 Other means of identification

Product number -
Other names Azetidine,3-(p-methoxyphenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7215-07-8 SDS

7215-07-8Relevant articles and documents

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides

Tarr, James C.,Wood, Michael R.,Noetzel, Meredith J.,Melancon, Bruce J.,Lamsal, Atin,Luscombe, Vincent B.,Rodriguez, Alice L.,Byers, Frank W.,Chang, Sichen,Cho, Hyekyung P.,Engers, Darren W.,Jones, Carrie K.,Niswender, Colleen M.,Wood, Michael W.,Brandon, Nicholas J.,Duggan, Mark E.,Jeffrey Conn,Bridges, Thomas M.,Lindsley, Craig W.

, p. 5179 - 5184 (2017/11/03)

Herein we describe the continued optimization of M4 positive allosteric modulators (PAMs) within the 5-amino-thieno[2,3-c]pyridazine series of compounds. In this letter, we disclose our studies on tertiary amides derived from substituted azetidines. This series provided excellent CNS penetration, which had been challenging to consistently achieve in other amide series. Efforts to mitigate high clearance, aided by metabolic softspot analysis, were unsuccessful and precluded this series from further consideration as a preclinical candidate. In the course of this study, we found that potassium tetrafluoroborate salts could be engaged in a tosyl hydrazone reductive cross coupling reaction, a previously unreported transformation, which expands the synthetic utility of the methodology.

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