7217-59-6

Basic information

• Product Name: 2-METHOXYBENZENETHIOL
• Synonyms: Benzenethiol, 2-methoxy-;2-Methoxythiophenol 98%;2-METHOXYTHIOPHENOL 2-METHOXYBENZENETHIOL;2-METHOXYTHIOPHENOL / 2-MERCAPTOANISOLE;2-Mercaptoanisole, 2-Methoxybenzenethiol, Thioguaiacol;2-Methoxybenzene-1-thiol;Thiocatechol O-methyl ether;2-Methoxybenzenethiol,97%
• CAS NO: 7217-59-6
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.2
• EINECS: 230-605-7
• Product Categories: Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles
• Mol File: 7217-59-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 99 °C8 mm Hg(lit.)
• Flash Point: 204 °F
• Appearance: Clear yellow/Liquid
• Density: 1.152 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.077mmHg at 25°C
• Refractive Index: n20/D 1.591(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: H2O: insoluble
• PKA: 6.62±0.43(Predicted)
• Sensitive: Stench
• Stability: Moisture Sensitive
• BRN: 2042178
• CAS DataBase Reference: 2-METHOXYBENZENETHIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYBENZENETHIOL(7217-59-6)
• EPA Substance Registry System: 2-METHOXYBENZENETHIOL(7217-59-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-37/39
• RIDADR: 3334
• WGK Germany: 3
• RTECS: DC1790000
• F: 10-13-23
• TSCA: T
• HazardClass: IRRITANT, STENCH
• Hazardous Substances Data: 7217-59-6(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 7217-59-6 differently. You can refer to the following data:
1. clear yellow liquid
2. Colorless to yellowish liquid; pungent, onion aroma.

Uses

Different sources of media describe the Uses of 7217-59-6 differently. You can refer to the following data:
1. 2-Methoxythiophenol is used in the synthesis of berberine-thiophenyl hybrids as multifunctional agents. Inhibition of acetylcholinesterase, butyrylcholinesterase and AB aggregation antioxidant activity.
2. 2-Methoxythiophenol was used in the synthesis of:(4S)-N-[(2S)-2-methy-3-(2-methoxyphenylthio)propanoyl]-4-phenyloxazolidin-2-one2-(4-fluorophenyl)-6-(2-methoxyphenylsulfanyl)imidazo[1,2-a]pyridine2-(2-methoxyphenylsulfanyl)benzoic acid

Aroma threshold values

Meaty type, very high strength odor, recommend smelling in a 0.10% solution or less.

Taste threshold values

Meaty sausage taste at 1 ppm in water.

General Description

2-Methoxythiophenol is a sulfur-containing compound that can be used as a flavoring agent.

InChI:InChI=1/C7H8OS/c1-8-6-4-2-3-5-7(6)9/h2-5,9H,1H3/p-1

Upstream product

• 766-51-8 2-Chloroanisole 
• 529-28-2 4-iodoanisol 
• 90-05-1 2-methoxy-phenol 
• 100-66-3 methoxybenzene 
• 7647-01-0 hydrogenchloride 
• 10130-87-7 o-Methoxybenzenesulfonyl chloride 
• 1070999-67-5 3-(2-methoxy-benzenesulfonyl)-2-(toluene-4-sulfonylmethyl)-quinoline 
• 1071094-99-9 3-(2-methoxy-benzenesulfonyl)-2-phenyl-quinoline 
• 18619-21-1 <(2-Methoxyphenyl)thio>acetic acid 
• 248584-44-3 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(2-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 31836-28-9 thiocarbonochloridic acid O-(2-methoxy-phenyl) ester 
• 75-08-1 ethanethiol 
• 2388-73-0 1-methoxy-2-(methylsulfanyl)benzene 
• 578-57-4 2-bromoanisole 

Downstream Products

• 57275-17-9 2-(o-Methoxyphenylthio)-benzoic acid 
• 82386-92-3 2-(2-Bromobenzylthio)anisole 
• 449814-54-4 (E)-3-(2-methoxyphenylthio)-3-methylamino-1-phenylpropenethione 
• 83193-30-0 2-[(2-methoxyphenyl)sulfanyl]benzaldehyde 
• 14065-22-6 1-methoxy-2-(phenylthio)benzene 
• 93534-64-6 1-((2-methoxyphenyl)thio)pyrrolidine-2,5-dione 
• 111375-57-6 2'-deoxy-5-<1-(2-methoxyphenylthio)ethyl>uridine 
• 112254-16-7 (2-methoxy-benzenesulfonyl)-acetone 
• 38477-80-4 1-methoxy-2-(2-propenylthio)benzene 
• 121782-67-0 C₁₆H₁₈O₂S₂ 
• 20912-14-5 (2-methoxylphenyl)-(2-nitrophenyl)thioether 
• 91901-31-4 (2-methoxyphenyl)(4-nitrophenyl)sulfane 
• 79506-64-2 2-((2-methoxyphenyl)thio)acetonitrile 
• 34257-56-2 1-(Ethylthio)-2-methoxybenzene 

Relevant articles and documents

Preparation method for synthesizing thiophenol compound based on sodium sulfide nonahydrate

The invention provides a preparation method for synthesizing a thiophenol compound based on sodium sulfide nonahydrate. In an inert gas protective atmosphere, substituted iodobenzene and a sulfhydrylation reagent are added into an aprotic polar solvent, then a copper salt catalyst and a ligand compound are orderly added into the solution, the mixed solution undergoes a reaction at a temperature of 90 to 120 DEG C for 12-24h, and the reaction solution is cooled to the room temperature and is acidized so that the product is obtained. The preparation method has the advantages of simple reaction conditions, good compatibility of functional groups, high yield and small environmental pollution. Thiophenol is an important intermediate for pharmaceutical chemical synthesis and has a very wide application range in fields of chemical raw materials, pesticides and medicines. The preparation method has a great use value and good social and economic benefits.

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Palladium catalyzed synthesis of aryl thiols: Sodium thiosulfate as a cheap and nontoxic mercapto surrogate

A Pd-catalyzed coupling reaction of ArBr/ArCl/ArOTf with sodium thiosulfate takes place in presence of Cs2CO3 at 80 °C. The reaction mixture is directly treated with Zn/HCl to afford aryl thiols in good to excellent yields.