721884-34-0Relevant articles and documents
A mechanochemical approach for the construction of carbon-carbon double bonds: Efficient syntheses of aryl/heteroaryl/aliphatic acrylates and nitriles
Jayalakshmi, Lakshmi Narayanan,Karuppasamy, Ayyanar,Stalindurai, Kesavan,Sivaramakarthikeyan, Ramar,Devadoss, Vellasamy,Ramalingan, Chennan
, p. 1322 - 1330 (2015)
An efficient method for the construction of carbon-carbon double bond has been developed from aromatic aldehydes and compounds with active methylene moieties in the presence of catalytic amount of solid sodium ethoxide via mechanochemical approach. This c
Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes
Ramadan, El Sayed,Sharshira, Essam M.,El Sokkary, Ramadan I.,Morsy, Noussa
, p. 389 - 397 (2018/05/30)
A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-Triazolidine-3-Thiones, and Knoevenagel condensation products was synthesized from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans in comparison with imipenem (intravenous β-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1H-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus C. albicans.
A Green and Facile Synthesis of Biopertinent Pyrazole-Decorated Nitriles and Acrylates under Catalyst-Free Conditions
Jayalakshmi, Lakshmi Narayanan,Stalindurai, Kesavan,Karuppasamy, Ayyanar,Sivaramakarthikeyan, Ramar,Devadoss, Vellasamy,Ramalingan, Chennan
supporting information, p. 1857 - 1861 (2015/08/06)
A green and efficient methodology has been developed for the construction of 2-[(1,3-diaryl-4-pyrazolyl)methylene]malononitriles, potent antioxidant molecules, in good to excellent yields in five minutes from 1,3-diarylpyrazole-4-carbaldehydes and malonon
Thiourea: An efficient and inexpensive catalyst for the Knoevenagel condensation of pyrazole derivates
Li, Jian-Ping,Qiu, Ji-Kuan,Li, Hui-Juan,Zhang, Gui-Sheng
experimental part, p. 268 - 271 (2011/11/29)
Thiourea is an inexpensive, efficient and mild catalyst for the synthesis of Knoevenagel condensation of pyrozoles derivate. In the presence of 10 mol% of thiourea, pyrazole aldehyde react with active methylene compound under microwave-assisted solvent-fr