721884-81-7

Basic information

• Product Name: (1S,3S)-3-AMINOCYCLOHEXANOL
• Synonyms: Trans-(3S,4S)-3-aMino-cyclohexanol hydrochloride;Cyclohexanol, 3-amino-, (1S,3S)-;(1S,3S)
• CAS NO: 721884-81-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 721884-81-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 70.6-70.9 °C
• Boiling Point: 201.1±33.0 °C(Predicted)
• Appearance: /
• Density: 1.037±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.09±0.40(Predicted)
• CAS DataBase Reference: (1S,3S)-3-AMINOCYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3S)-3-AMINOCYCLOHEXANOL(721884-81-7)
• EPA Substance Registry System: (1S,3S)-3-AMINOCYCLOHEXANOL(721884-81-7)

Safety Data

• Hazardous Substances Data: 721884-81-7(Hazardous Substances Data)

Usage

General Description

(1S,3S)-3-Aminocyclohexanol, also known as trans-3-Aminocyclohexanol, is a chemical compound that consists of a cyclohexane ring with an amino group and a hydroxyl group attached to it. It is a chiral compound, with two possible enantiomers: (1S,3S) and (1R,3R). (1S,3S)-3-Aminocyclohexanol is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It also has potential applications in the field of asymmetric synthesis, due to its chiral nature. Additionally, it has been investigated for its potential use as a ligand in metal-catalyzed asymmetric reactions. Overall, (1S,3S)-3-Aminocyclohexanol is a versatile chemical with various potential uses in the field of organic chemistry.

Upstream product

• 1257303-70-0 (1S,3S)-(3-hydroxycyclohexyl)ammonium (R)-mandelate 
• 750649-39-9 ((1S,3S)-3-hydroxycyclohexyl)carbamic acid benzyl ester 
• 750649-39-9 (+/-)-trans-(3-hydroxycyclohexyl)carbamic acid benzyl ester 
• 13941-94-1 (rac)-trans-1-(3-hydroxycyclohexyl)benzamide 
• 6850-39-1 3-aminocyclohexanol 

Downstream Products

• 1397712-48-9 (1S,3S)-3-(6,6-dimethyl-4,4-dioxo-5-phenyl-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino)cyclohexanol 
• 1439358-23-2 C₁₉H₂₄N₄O₄S 
• 1146615-90-8 (1S,3S)-3-(3-bromo-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol 

Relevant articles and documents

Diastereoisomeric salt formation and enzyme-catalyzed kinetic resolution as complementary methods for the chiral separation of cis-/trans-enantiomers of 3-aminocyclohexanol

This contribution demonstrates the preparative-scale synthesis of (1S,3S)-3-aminocyclohexanol by either enzymatic kinetic resolution of Cbz-protected 3-aminocyclohexanols or direct diastereoisomeric salt formation with (R)-mandelic acid. The salt formation demonstrates how a single enantiomer, (1S,3S)-3-aminocyclohexanol (R)-mandelate, can be effectively isolated from the cis/trans racemic mixture and subsequently converted to the free amine, (1S,3S)-3-aminocyclohexanol, by ion-exchange chromatography. We have also demonstrated how the other three enantiomers of 3-aminocyclohexanol can be prepared by either diastereoisomeric salt formation or enzymatic kinetic resolution.

2-Substituted-1H-benz(de)-isoquinoline-1,3-(2H)-diones

Compounds of the following formula STR1 wherein R1 and R2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, STR2 wherein n is 1 or 2 and R3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.