721884-83-9Relevant academic research and scientific papers
Resolution of trans-3-aminocyclohexanol
Bernardelli, Patrick,Bladon, Michael,Lorthiois, Edwige,Manage, Ajith C.,Vergne, Fabrice,Wrigglesworth, Roger
, p. 1451 - 1455 (2007/10/03)
(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymatic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess.
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives
Vergne, Fabrice,Bernardelli, Patrick,Lorthiois, Edwige,Pham, Nga,Proust, Emmanuelle,Oliveira, Chrystelle,Mafroud, Abdel-Kader,Ducrot, Pierre,Wrigglesworth, Roger,Berlioz-Seux, Fran?oise,Coleon, Francis,Chevalier, Eric,Moreau, Fran?ois,Idrissi, Moulay,Tertre, Anita,Descours, Arnaud,Berna, Patrick,Li, Mei
, p. 4615 - 4621 (2007/10/03)
The synthesis and optimization of pharmacokinetic parameters of structurally novel small PDE7 inhibitors is discussed.
Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors
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, (2008/06/13)
The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following Formula I: in which, Y is S or O, R1 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl or a polycyclic group, optionally substituted, R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl or aryl optionally substituted, R3 is X2—R′3, in which X2 is a binding group and R′3 is cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl, or a polycyclic group; optionally substituted, or their pharmaceutically acceptable derivatives, a compound of Formula I, for their preparation, and processes for pharmaceutical compositions containing methods of using the compounds for the treatment of disorders for which a treatment by a PDE7 inhibitor is relevant.
